Research Progress on Mechanism of Chinese Herbal Monomers and Compound Formulas Against Lung Cancer Through Glucose Metabolic Reprogramming
10.3971/j.issn.1000-8578.2025.25.0405
- VernacularTitle:中药单体及复方通过调控糖代谢重编程抗肺癌的作用机制研究进展
- Author:
Zhen WANG
1
;
Honglei GUO
2
;
Aidi WANG
2
;
Lin MA
2
;
Baoshan LIU
2
Author Information
1. Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
2. Department of Traditional Chinese Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.
- Publication Type:REVIEWS
- Keywords:
Traditional Chinese medicine;
Monomer or compound;
Glucose metabolic reprogramming;
Lung cancer;
Mechanism
- From:
Cancer Research on Prevention and Treatment
2025;52(12):1021-1028
- CountryChina
- Language:Chinese
-
Abstract:
Glucose metabolic reprogramming is important in promoting the occurrence and development of malignant tumors and meeting the high demands of the malignant proliferation of tumor cells. An in-depth investigation of the mechanism of glucose metabolic reprogramming in lung cancer is important for the development of effective therapeutic strategies for lung cancer. Traditional Chinese medicine (TCM) is characterized by multiple components, targets, and pathways and can exert antitumor effects through multiple mechanisms. This article illustrates systematically the mechanism of action of Chinese herbal monomers and compound formulas regulating glucose metabolic reprogramming in lung cancer and explores deeply their regulatory effects on key enzymes of glycolysis and metabolism-related signaling pathways, and their potential in overcoming the drug resistance of lung cancer. It aims to provide a reference basis for the study of therapeutic targets and mechanisms of action of TCM in prevention and treatment of lung cancer and theoretical sources for the research and development of new medicines.
