Research progress on the mechanisms of alkaloid components against colorectal cancer
- VernacularTitle:生物碱类成分抗结直肠癌的作用机制研究进展
- Author:
Di LIU
1
;
Zongyue GAO
2
;
Chengzhi WANG
3
;
Yifan LIU
1
;
Dan CAO
1
;
Tiantian DONG
1
Author Information
1. The Second Clinical Medical College，Henan University of Chinese Medicine，Zhengzhou 450002，China
2. Anorectal Department Diagnosis and Treatment Center，Henan Provincial Hospital of Traditional Chinese Medicine/the Second Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450002，China
3. The First Clinical Medical College of Henan University of Chinese Medicine，Zhengzhou 450004，China
- Publication Type:Journal Article
- Keywords:
alkaloids;
active ingredient;
colorectal cancer;
mechanism;
signaling pathways;
berberine
- From:
China Pharmacy
2025;36(24):3143-3148
- CountryChina
- Language:Chinese
-
Abstract:
The incidence and mortality of colorectal cancer （CRC） in China have been on a steady rise. Current therapeutic approaches can curb the progression of CRC to a certain extent， but issues such as toxic side effects， high metastasis rate， and high recurrence rate cannot be ignored. In recent years， alkaloid components derived from traditional Chinese medicine （TCM） have demonstrated tremendous potential in the prevention and treatment of CRC due to their diverse structures， complex mechanisms， and broad biological activities. Representative alkaloids such as matrine， berberine and evodiamine exert anti-CRC effects through multiple pathways： regulating signaling pathways including Wnt/β-catenin， nuclear factor-κB， signal transducer and activator of transcription 3， and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin； inhibiting the proliferation， migration， and invasion of CRC cells； inducing cell apoptosis and autophagy； arresting the cell cycle progression； regulating the gut microbiota； suppressing cellular glycolysis； and inducing ferroptosis.
