Research progress on the mechanism of traditional Chinese medicine in regulating autophagy to intervene in ovulatory disorders
- VernacularTitle:中药通过调控自噬干预排卵障碍的作用机制研究进展
- Author:
Yaxue QU
1
;
Ying DING
1
;
Shanshan HAN
1
;
Zhaoheng SUN
1
;
Wenchao XING
2
Author Information
1. Dept. of Pediatrics，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China;College of Pediatrics，Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Dept. of Pediatrics，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
- Publication Type:Journal Article
- Keywords:
autophagy;
ovulatory disorders;
traditional Chinese medicine;
mechanism of action
- From:
China Pharmacy
2025;36(24):3132-3136
- CountryChina
- Language:Chinese
-
Abstract:
Ovulatory disorders are mainly characterized by abnormal follicular maturation or ovulation， with complex etiologies and a lack of effective prevention and treatment methods. Autophagy dysfunction is closely related to the generation and progression of ovulatory disorders. This article systematically elucidates the mechanisms of TCM on follicular development and ovulatory disorders from the perspective of autophagy. It also reviews relevant studies on how TCM regulates autophagy to influence follicular development and improve ovulatory disorders. The findings reveal that TCM monomers/active ingredients （leonurine， total flavonoids from Eucommia ulmoides， alpinetin， icariin， etc.） and compound formulas （including Cangfu daotan decoction， Guishen yugong decoction， Zhuluan decoction， Yishen yangluan formula， Guishen pill， etc.） improve the follicular microenvironment， regulate sex hormone levels， and reduce follicular atresia by regulating autophagy-related genes and signaling pathways such as phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin and AMP-activated protein kinase. These actions thereby promote normal follicular development and ovulation， and delay ovarian aging. Most research in this field is based on cellular and animal experiments， often focusing on a single signaling pathway or factor. Some studies fail to fully reflect the individualized treatment characteristics of TCM that emphasize “syndrome differentiation and treatment”， highlighting the urgent need for further investigation.
