Clinical observation of platelet-rich plasma intrauterine infusion combined with Gushen antai pills in the treatment of recurrent abortion
- VernacularTitle:富血小板血浆宫内输注联合固肾安胎丸治疗复发性流产的临床观察
- Author:
Sainan ZHANG
1
;
Junfeng LI
1
;
Shuwen XIN
1
;
Aihong BAI
1
;
Rongxiang LI
1
;
Xiuhong FU
2
Author Information
1. Reproductive Medicine and Genetics Center，Luohe Central Hospital，Henan Luohe 462300，China;Key Laboratory of Fertility Protection and Eugenics in Henan Province，Henan Luohe 462300，China
2. Reproductive Medicine and Genetics Center，Luohe Central Hospital，Henan Luohe 462300，China
- Publication Type:Journal Article
- Keywords:
platelet-rich plasma;
Gushen antai pills;
recurrent abortion;
endometrial receptivity;
hormone;
efficacy
- From:
China Pharmacy
2025;36(24):3102-3106
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the efficacy of platelet-rich plasma （PRP） intrauterine infusion combined with Gushen antai pills in the treatment of recurrent abortion （RSA） and its impacts on endometrial receptivity and hormone levels in patients. METHODS A total of 108 patients with RSA treated in our hospital from January 2021 to January 2024 were selected and evenly divided into control group and study group using the random number table method， with 54 cases in each group. On the basis of conventional treatment， patients in the control group were administered with Gushen antai pills， while patients in the study group received PRP intrauterine infusion combined with Gushen antai pills. The clinical efficacy， TCM syndrome scores before and after treatment， endometrial receptivity [endometrial thickness （EST）， spiral artery resistance index （RI）， and pulsatility index （PI）]， hormone [progesterone （P）， estradiol （E2）， and human chorionic gonadotropin （HCG）] levels， as well as pregnancy outcomes， were compared between the two groups. Additionally， the occurrence of adverse reactions in both groups was recorded. RESULTS The total effective rate （91.44% vs. 81.48%） and infant live birth rate （96.30% vs. 83.33%） of the study group were significantly higher than those of the control group （P＜0.05）. Following treatment， various TCM syndrome scores and total score， spiral artery RI and PI levels in both groups were markedly lower than those in the same groups before treatment， with the study group showing significantly lower levels than the control group（P＜0.05）. Conversely， the P， E2， HCG and EST levels in both groups were significantly higher than those in the same groups before treatment， and the study group exhibited notably higher levels than the control group （P＜0.05）. There was no statistically significant difference in the total incidence of adverse reactions between the two groups （P＞0.05）. CONCLUSIONS PRP intrauterine infusion combined with Gushen antai pills has good clinical efficacy in the treatment of RSA. It can improve TCM syndromes， enhance endometrial receptivity， regulate hormone levels and improve pregnancy outcomes， and it is highly safe.
