Effects of Single Dose of Lidocaine on Agitation in Pediatric Patient undergoing Laparoscopic Hernia Repair ： A Clinical Observation
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2021.0518
- VernacularTitle:静脉输注利多卡因对腹腔镜疝修补术患儿苏醒期躁动的临床观察
- Author:
Dong-ni XU
1
;
Ting LIU
1
;
Pei-zong WANG
2
;
Ya-nan LU
1
Author Information
1. Department of Anesthesiology， Sun Yat-sen Memorial Hospital of Sun Yat-sen University， Guangzhou 510120，China
2. Department of Anesthesiology， Sun Yat-sen University Cancer Center， Guangzhou 510060，China
- Publication Type:Journal Article
- Keywords:
laparoscopic hernia repair;
Lidocaine;
Dexmedetomidine;
agitation
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(5):783-789
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effects of single dose of intravenous infusion Lidocaine on emergence agitation in small children undergoing laparoscopic hernia repair. MethodsA total of 60 children aged 2 to 4 years with ASA I-Ⅱ grades undergoing laparoscopic hernia repair under general anesthesia were selected as the research objects. According to the random number table， they were divided into a complete blank control group （group C） and a positive control， Dexmedetomidine group （D group）， lidocaine group （L group）， 20 cases in each group. The primary outcome measures include the WATCHA scale agitation score， the incidence of agitation after extubation， and the rescue medication times. The secondary observation indicators include the average sevoflurane inhalation concentration during the operation， the early postoperative analgesia score， extubation time， time stay in PACU，the total amount of tramadol. Results①The postoperative WATCHA agitation scores of children in group D and L were lower than those in group C； the incidence of agitation in children in group D and L was 15% and 20%， respectively， which were both lower than 70% in group C； remedy plus The number of drug users was 10%， which was 55% lower than that of group C； with Bonferroni correction， the difference between pairwise comparisons was statistically significant （P<0.017）. ②In the children of group D and L， the average inhalation concentration of sevoflurane during operation was lower than that of group C； The extubation time of group L （12.05±2.96） min was lower than that of group D； the residence time in the recovery room （51.50±9.61） min was the shortest. Less than D and C groups， after Bonferroni adjustment， the difference was statistically significant （P<0.017）. ③The incidence of tramadol dosage at 48 hours postoperatively and the incidence of new maladaptation at 24 hours postoperatively in group D and group L were lower than those in group C. After Bonferroni correction， the difference was statistically significant （P<0.017）. ④HR2， HR3 and HR4 of group D and L were lower than group C. After Bonferroni correction， the difference was statistically significant （P<0.017）. ConclusionInfusion of lidocaine and dexmedetomidine can reduce postoperative agitation incidence in children undergoing laparoscopic hernia resection. Intravenous infusion of lidocaine or dexmedetomidine can reduce sevoflurane use， and the perioperative heart rate of children is more stable. Compared with dexmedetomidine， the lidocaine group had a shorter extubation time， PACU stay time， and faster recovery. Intravenous infusion of lidocaine or dexmedetomidine can reduce postoperative analgesics' dosage and the incidence of postoperative new maladjustment.
