Correlation between Intratumoral Fat Content and Pathological Grade of Hepatocellular Carcinoma
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2021.0517
- VernacularTitle:肝细胞癌患者肿瘤内脂肪含量与病理分级的相关性
- Author:
Hai XU
1
;
Xiao yun LIANG
2
;
Yang-di WANG
3
;
Xue-fang HU
3
;
Si-ya SHI
3
;
Yan-ji LUO
3
Author Information
1. Department of Interventional Radiology， The First Affiliated Hospital of Sun Yat-sen University， Guangzhou 510080， China
2. Department of Medical Imaging， Affiliated Hospital of Traditional Chinese Medicine， Guangzhou Medical University， Guangzhou 510130， China
3. Department of Radiology， The First Affiliated Hospital of Sun Yat-sen University， Guangzhou 510080， China
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
magnetic resonance imaging;
degree of pathological differentiation;
chemical shift;
fat volume fraction
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(5):778-782
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare the difference of fat content in HCC tumors with different pathological grades， and to analyze the potential value of fat content in predicting the pathological grades of HCC. MethodsTotally 96 patients with HCC who underwent MRI Dixon examination and were pathologically confirmed in the First Affiliated Hospital of Sun Yat-sen University between January 2009 and July 2017 were retrospectively analyzed. They were divided into non-poorly differentiated group and poorly differentiated group according to Edmondson-Steiner pathological grading. Two observers measured the fat volume fraction （FVF） in the lesions of the two groups. The difference of FVF between the two groups was compared. The potential value of tumor FVF in predicting the pathological grade of HCC was analyzed. ResultsThe results of FVF between 2 observers were consistent （ICC >0.75）. The FVF value in the non-poorly differentiated HCC group ［15.75 （12.37~21.32）］ was higher than that in the poorly differentiated HCC group［13.45， （8.48~21.10）， Z=-1.972， P=0.049］. The AUC value of FVF in differentiating the pathological grade of HCC was 0.645. When the FVF was greater than or equal to 15.4， the sensitivity and specificity for the diagnosis of non-poorly differentiated HCC was 53% and 77%， respectively. ConclusionThe examination of MRI Dixon can comprehensively and accurately evaluate the FVF in HCC tumors， and the FVF in HCC tumors is helpful for the preoperative evaluation of the pathological grade of HCC.
