Maternal Lipid Levels during Pregnancy and Their Relation with Pregnancy Complications
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2021.0515
- VernacularTitle:不同孕期血脂值与妊娠并发症的关系
- Author:
Shu-fan YUE
1
;
Ling PEI
1
;
Wen-zhan CHEN
1
;
Rui ZENG
1
;
Xiao-pei CAO
1
Author Information
1. Endocrinology and Metabolism Department， The First Affiliated Hospital， SUN Yat-sen University， Guangzhou 510080， China
- Publication Type:Journal Article
- Keywords:
maternal lipid levels during pregnancy;
reference range;
pregnancy complications
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(5):762-770
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo determine the serum lipid levels during different trimesters of pregnancy and investigate their relation with pregnancy complications. MethodsThe study recruited 1 017 pregnant women who were examined and delivered in the First Affiliated Hospital of Sun Yat-sen University between January 2018 and August 2018. Serum lipid levels during different trimesters of pregnancy were reviewed. Univariate and multivariate logistic regression models were used to analyze the risk factors of pregnancy complications and the relation between lipid levels and pregnancy complications. The threshold values of lipid levels during pregnancy were determined based on the 95th percentile. ResultsTotal lipid levels during pregnancy increased， with triglyceride （TG） levels increasing the most. Age， pre-pregnancy body mass index （p-BMI） and lipid levels were associated with pregnancy complications. In the second and third trimesters， the increased level of TG and decreased level of high-density lipoprotein cholesterol （HDL-c） were correlated with increased risk of pregnancy complications. The threshold values of lipid levels during pregnancy in our hospital were total cholesterol （TC）<6.09 mmol/L， TG<2.39 mmol/L， HDL-c>1.17 mmol/L and low-density lipoprotein cholesterol （LDL-c）<3.61 mmol/L in the first trimester； TC<7.80 mmol/L， TG<3.51 mmol/L， HDL-c>1.38 mmol/L and LDL-c<4.73 mmol/L in the second trimester； TC<8.50 mmol/L， TG<5.61 mmol/L， HDL-c>1.28 mmol/L and LDL-c<5.25 mmol/L in the third trimester. ConclusionsLipid levels vary with the stage of pregnancy. In the second and third trimesters of pregnancy， the increased level of TG and decreased level of HDL-c are associated with increased risk of pregnancy complications.
