The Reviews of Sporotrichosis and the Sporothrix Complex
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2021.0501
- VernacularTitle:孢子丝菌病及其病原真菌的再认识
- Author:
Huai-qiu HUANG
1
Author Information
1. Department of Dermatology and Venereology， The Third Affiliated Hospital of Sun Yat-sen University， Guangzhou 510630， China
- Publication Type:Review
- Keywords:
Sporotichosis;
Sporothrix complex;
epidemiology;
genomic;
transcriptional
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(5):641-650
- CountryChina
- Language:Chinese
-
Abstract:
Sporotrichosis is a worldwide-distributed zoonotic mycosis caused by the dimorphic fungi Sporothrix complex， and it can initiate the chronic infection of skin， mucosa， subcutaneous cellular tissue and adjacent lymphatic vessels. The lesions are usually restricted to the skin and local lymphatic vessels， but the fungi also can disseminate to other organs and lead to a systemic disease. The Sporothrix complex is composed of at least six pathogenic species， which have differences in microscopic morphology， genetics， epidemiology， drug resistance and pathogenicity. The pathogenic studies of Sporothrix complex focus on melanin， adhesions and chitin. Our study on the whole genome and transcription sequencing of Sporothrix complex has been completed， providing a basis for the pathogenesis of Sporothrix disease.
