The Pathogenic Evolution and Therapeutic Approaches of Rheumatoid Arthritis Complicated by Sarcopenia Based on the Theory of 'Bi （痹） of both Body and Viscera'
10.13288/j.11-2166/r.2025.23.009
- VernacularTitle:运用“体脏合痹”理论探析类风湿关节炎并发肌少症的病机演化与辨治
- Author:
Shuai ZHONG
1
;
Ping JIANG
1
;
Xiaohu ZHAO
1
;
Yuan LIU
1
;
Xuanhe TIAN
1
Author Information
1. First Clinical Medical College，Shandong University of Traditional Chinese Medicine，Jinan，250014
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
sarcopenia;
bi （痹） of both body and viscera;
disharmony of ying （营） and wei （卫）;
bi （痹） disease;
atrophy syndrome
- From:
Journal of Traditional Chinese Medicine
2025;66(23):2443-2446
- CountryChina
- Language:Chinese
-
Abstract:
Based on the theory of 'bi （痹） of both body and viscera'， this paper systematically discussed the pathogenic evolution of rheumatoid arthritis （RA） complicated by sarcopenia from the perspective of traditional Chinese medicine （TCM）. It is proposed that a transformation pathway is muscle bi to spleen bi and then atrophy bi， and the core pathogenesis is diaharmony of ying （营） and wei （卫）. Combining modern molecular biology research， it is suggested that imbalances in skeletal muscle homeostasis mediated by the tumor necrosis factor-like weak inducer of apoptosis-ibroblast growth factor-inducible 14 （TWEAK-Fn14） axis may provide the material basis for the evolution of this disease. Furthermore， this authors proposed TCM treatment strategies， including "regulating and tonifying ying and wei， warming yang and moving bi， nourishing the viscera by supporting the body"， and "promoting the spleen and resolving turbidity， clearing heat and promoting circulation， regulating the organs and calming the body". These strategies emphasize the simultaneous treatment of body and viscera， integrated prevention and treatment， so as to provide TCM theoretical foundation and clinical approaches for preventing and treating RA complicated by sarcopenia.
