Correlation Analysis between SUVmax in Dual-phase 68Ga-PSMA-11 PET/CT and the Clinicopathologic Features of Patients with Prostate Cancer
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2021.0116
- VernacularTitle:68Ga-PSMA-11 PET/CT双时相SUVmax与前列腺癌临床病理特征的相关性
- Author:
Jian-fang LI
1
;
Qi-chang WAN
1
;
Lu-ping QIN
1
;
Liang-jun XIE
1
;
Jin-ping LI
1
;
Qing-yu WU
1
;
Zi-chao LIANG
2
;
Mu-hua CHENG
1
Author Information
1. Department of Nuclear Medicine， The Third Affiliated Hospital of Sun Yat-sen University， Guangzhou 510630， China
2. Department of Medical Statistics， School of Public Health， Sun Yat-sen University， Guangzhou 510080， China
- Publication Type:Journal Article
- Keywords:
prostate cancer;
prostate specific membrane antigen （PSMA）;
68Ga;
positron emission tomography （PET）;
gleason score
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(3):448-454
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveThe purpose of this study was to analyze the correlation between SUVmax on primary prostate lesion of two-phase 68Ga-PSMA-11 PET/CT and the clinicopathological features of patients with preliminary diagnosis of prostate cancer. MethodsPET/CT images of 19 patients with prostate cancer first diagnosed in our hospital from November 2017 to September 2020， aged 69.0±7.4 years， were collected. All patients underwent 68Ga-PSMA-11 PET/CT dual-phase examination， and radical resection of prostate cancer was performed within two weeks. Semi-quantitative parameters of 68Ga-PSMA-11 PET/CT on primary prostate cancer， SUVmax1 in the standard phase imaging， SUVmax2 in the delayed phase imaging and SUVmax3 （difference between SUVmax2 and SUVmax1）， were measured by automatic segmentation algorithm method. Clinical and pathological data of each patient were collected. Mann-Whitney U test and ROC curve analysis were used to compare SUVmax and the clinicopathological characteristics of patients in two independent samples. P<0.05 was considered as statistically significant difference. ResultsThe differences of SUVmax1， SUVmax2 and SUVmax3 between GS≤7 group and >7 group were statistically significant（P＜0.05）， and the areas under the ROC curves were 0.845， 0.845 and 0.893， respectively. SUVmax1， SUVmax2 and SUVmax3 were significantly different between ISUP grade ≤2 group and >2 group （P<0.05）， and the areas under the ROC curve were 0.773， 0.784 and 0.852， respectively. The difference of SUVmax3 between T stage ≤T2 group and >T2 group was statistically significant （P<0.05）， while the difference of SUVmax1 and SUVmax2 between T stage ≤T2 group and >T2 group was not statistically significant （P>0.05）. The difference of SUVmax3 between D’ Amico low-medium-risk group and high-risk group was statistically significant （P<0.05）， while the difference of SUVmax1 and SUVmax2 between D’ Amico low-medium-risk group and high-risk group was not statistically significant （P>0.05）. There was no significant difference in SUVmax1， SUVmax2 and SUVmax3 between total PSA ≤20 ng/mL group and >20 ng/mL group （P>0.05）. SUVmax1， SUVmax2 and SUVmax3 were significantly different between positive nerve invasion group and negative group （P<0.05）， and the areas under the ROC curves were 0.872， 0.923 and 0.974， respectively. ConclusionsSUVmax2 and SUVmax3 were positively correlated with multiple clinical and pathological features of prostate cancer. Compared with standard phase imaging， dual-phase imaging of 68Ga-PSMA-11 PET/CT may provide more favorable value in predicting the clinical and pathological features of prostate cancer patients before surgery.
