Pathological Changes of Vogt-Koyanagi Harada Observed by Optical Coherence Tomography Angiography
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2021.0112
- VernacularTitle:光学相干断层扫描血管成像技术观察下的Vogt-小柳原田病的病理变化
- Author:
Hai-ping ZHANG
1
;
Wei CHI
2
;
Jin YUAN
3
;
Xiao-yuan YE
2
;
Li-shi SU
2
;
Fan LI
2
;
Ye TIAN
1
;
Xia HUA
1
Author Information
1. Department of Ophthalmology， Second Hospital of Tianjin Medical University， Tianjin 300211， China
2. Department of Ocular Immunity and Uveitis， Zhongshan Ophthalmic Center， Sun Yat-sen University， Guangzhou 510060， China
3. Department of Cornea， Zhongshan Ophthalmic Center， Sun Yat-sen University， Guangzhou 510060， China
- Publication Type:Journal Article
- Keywords:
vogt-koyanagi-harada syndrome;
swept‐source optical coherence tomography angiography;
quantitative analysis
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(3):418-424
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the differences of retina and choroid microvasculature between Vogt-Koyanagi-Harada （VKH） patients in convalescent stage and healthy people. MethodsIn this retrospective study， 12 Vogt-Koyanagi-Harada patients in convalescent stage （20 eyes）， and 13 healthy people （21 eyes） as controls were examined by Swept-Source optical coherence tomography angiography （SS-OCTA， PLEX Elite 9000，Carl Zeiss）. The area of the foveal avascular zone （FAZ） of the superficial capillary plexus （SCP） of the retina， the acircularity index （AI）， the vascular density of the superficial （SCP） and deep capillary plexus （DCP）， and the vascular density of choriocapillaris （CC） were analyzed by ImageJ software. The subfoveal choroidal thickness （SFCT） is measured by the built-in software of PLEX Elite 9000. t test and Mann-Whitney U test were used for statistical analysis. ResultsFAZ area of the Vogt-Koyanagi-Harada patients in convalescent stage was significantly smaller than that of healthy people （P=0.004）. The vascular density of SCP （6mm）， SCP （3mm） and DCP （6mm） in the VKH group （48.14±3.65）%， （47.73±3.23）%， （48.53±1.89）%， respectively， was also lower than that of the normal control group （49.84±1.56）%， （48.23±2.41）%， （50.31±1.58）%）. However， only the vascular density of DCP （6 mm） in the VKH group was statistically different from that of the normal control group （P=0.002）. The vascular density of SCP （1 mm） in the VKH group （29.82±7.04）% was significantly higher than that of the normal control group （25.59±5.44）%， and there was a statistical difference （P=0.037）. SFCT （408.70±66.97） μm was also significantly higher than the normal control group （254.00±54.48） μm （P=0.000）. On the other hand， the vascular density of choriocapillaris in the VKH group was not significantly different from that in the normal control group （P=0.095）. ConclusionsSS-OCTA examination can discover the changes that the FAZ area in SCP of the VKH patients in convalescent stage has decreased due to the blood vessels compensatory increase in the superficial capillary plexus within 1mm around the macular fovea. The decrease in the vascular density of the DCP can also indicate that the retinal blood supply of VKH patients in convalescent stage has not been fully restored.
