Correlation Between Lipoprotein a Level and Major Adverse Cardiovascular Events in Patients with Coronary Heart Disease Within 1 Year After Percutaneous Coronary Intervention
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2021.0109
- VernacularTitle:脂蛋白a水平与CHD患者PCI术后1年内主要不良心血管事件的相关性
- Author:
Su-zhen LIANG
1
;
Zhuo-shan HUANG
1
;
Ye-sheng LING
1
;
Jin-lai LIU
1
;
Xiao-xian QIAN
1
Author Information
1. Department of Cardiology， The Third Affiliated Hospital of Sun Yat-sen University//Institute of Integrated Chinese and Western Medicine， Sun Yat-sen University， Guangzhou 510630， China
- Publication Type:Journal Article
- Keywords:
lipoprotein a;
coronary heart disease;
percutaneous coronary intervention;
major adverse cardiovascular event
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(3):392-399
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the association between lipoprotein a ［Lp （a）］ and major adverse cardiovascular events （MACE） in patients with coronary heart disease （CHD） within 1 year after percutaneous coronary intervention （PCI）. MethodsOur study consecutively included 297 CHD patients who underwent PCI in our hospital from January 1， 2013 to December 31， 2014 and finished follow-up visits 1 year later. All patients were divided into 3 groups according to Lp（a）≤150mg/L， 150mg/L＜Lp（a）≤300mg/L and Lp（a）＞300mg/L. MACE occurrences were recorded. MACE is defined as hospitalization for recurrent angina pectoris， unplanned revascularization， acute myocardial infarction， acute heart failure and cardiogenic death. The different incidences of MACE within one year after PCI between patients with different Lp（a） levels were compared by univariate and multivariate survival analysis. ResultsThe average event-free survival time of 297 patients was （11.41±2.04） months. A total of 30 patients suffered from MACE， and the incidence of MACE was 10.1%. After constructing the event-free survival curves and comparing the survival rate by Log-rank test， it was found that patients with LP （a） > 300mg/L had a higher incidence of MACE. Cox proportional hazards regression models were used for multivariate adjustment. As a quantitative variable， elevated Lp（a） level was risk factor of MACE occurrence in CHD patients within 1 year after PCI ［hazard ratio（HR） per 1-SD increase 1.76， 95% confidence interval （CI）： 1.41～2.19， P<0.001］. As a categorical variable， Lp （a） > 300mg/L was also positively correlated with MACE occurrence within in CHD patients 1 year after PCI （HR 2.25， 95%CI： 1.38～3.67， P=0.001）. ConclusionsThe higher the level of Lp（a）， the higher the incidence of MACE within 1 year after PCI in CHD patients. Lp（a） is an independent risk factor for MACE occurrence within 1 year after PCI in CHD patients.
