The regulatory role and mechanism of microRNA in cholestasis
- VernacularTitle:微RNA对胆汁淤积的调控作用及其机制
- Author:
Linlin WANG
1
;
Zhengwang ZHU
1
;
Jinghan ZHAO
1
;
Ruixue MA
1
;
Bing WANG
2
;
Pingsheng ZHU
1
;
Mingsan MIAO
3
Author Information
- Publication Type:Review
- Keywords: Cholestasis; MicroRNAs; Gene Expression Regulation
- From: Journal of Clinical Hepatology 2025;41(10):2187-2194
- CountryChina
- Language:Chinese
- Abstract: As a type of endogenous small non-coding RNA， microRNA （miRNA） can regulate gene expression and thereby intervene against the development and progression of cardiovascular diseases， neurodegenerative diseases， metabolic diseases， and autoimmune diseases. The pathogenesis of cholestasis is complex and is mainly associated with the metabolism and transport of bile acids， oxidative stress， inflammatory response， and intestinal flora. Currently， ursodeoxycholic acid is the preferred drug for the clinical treatment of cholestasis， but it may cause adverse reactions and exhibit poor efficacy in some patients. Studies have shown that miRNA can intervene in the disease process of cholestasis through multiple mechanisms such as regulating bile acid metabolism and transport， alleviating oxidative stress， inhibiting inflammatory response， improving cholangiocyte proliferation， and regulating intestinal flora. It can be used as a new biomarker and action target for cholestasis， with high research potential and value. Therefore， this article summarizes the role and mechanisms of miRNA in regulating cholestasis in recent years， in order to provide a reference for further research on the prevention and treatment of cholestasis by targeting miRNA.
