Mechanism of action of the cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway in liver diseases and research advances in therapeutic targets
- VernacularTitle:cGAS-STING通路在肝脏疾病中的作用机制与治疗靶点研究进展
- Author:
Yujie ZHAI
1
;
Xiangxiang LI
2
;
Chujiang WU
2
;
Yanan ZHANG
2
;
Yuxin HE
2
;
Zhongyu LIU
2
;
Jiucong ZHANG
2
;
Bin LIANG
3
Author Information
- Publication Type:Review
- Keywords: Liver Diseases; cGAS-STING Signaling Pathway; Pathologic Processes; Therapeutics
- From: Journal of Clinical Hepatology 2025;41(10):2180-2186
- CountryChina
- Language:Chinese
- Abstract: Liver diseases are a group of complex clinical conditions caused by various factors and can lead to hepatocyte damage and liver dysfunction， posing a serious threat to human health. The cyclic GMP-AMP synthase （cGAS）-stimulator of interferon genes （STING） signaling pathway plays a key regulatory role in the course of liver diseases and is involved in the development， progression， and treatment of various diseases such as viral hepatitis， nonalcoholic fatty liver disease， liver fibrosis， and liver cancer. This article reviews the regulatory mechanisms of the cGAS-STING signaling pathway in processes such as inflammation， autophagy， antiviral response， and oxidative stress， analyzes its molecular function in liver diseases， and explores its application prospect as a potential target for the treatment of liver diseases， in order to provide a theoretical basis for developing novel therapeutic strategies for liver diseases.
