Pharmacological action of astragaloside Ⅳ in the prevention and treatment of liver diseases and its mechanism

VernacularTitle:黄芪甲苷防治肝脏疾病的药理作用及其机制
Author: Ke FU ¹ ; Shu DAI ² ; Juan YOU ¹ ; Chen YANG ¹ ; Xiaoli LI ¹ ; Li ZENG ¹ ; Shiyun PU ¹
Author Information

1. Department of Pharmacy， The Fifth People’s Hospital of Chengdu， Chengdu 611130， China
2. School of Pharmacy， Chengdu University of Traditional Chinese Medicine， Chengdu 611137， China
Publication Type:Review
Keywords: Liver Diseases; Astragaloside Ⅳ; Molecular Mechanisms of Pharmacological Action
From: Journal of Clinical Hepatology 2025;41(10):2174-2179
CountryChina
Language:Chinese
Abstract: Astragaloside Ⅳ （AS-Ⅳ） is a natural triterpenoid saponin compound derived from Astragalus membranaceus and has shown significant potential in the regulation of liver diseases. This article reviews the latest research advances in AS-Ⅳ in the field of liver diseases in China and globally， and it is found that AS-Ⅳ exerts a liver-protecting effect by regulating lipid metabolism， exerting an anti-tumor/anti-inflammatory/anti-fibrotic effect， and modulating gut microbiota. Its mechanism of action involves multiple signaling pathways， such as AMPK， NLRP3， NF-κB， JAK2/STAT3， and Nrf2. These research findings provide a scientific basis for the development of liver-protecting drugs or functional foods based on the natural product AS-Ⅳ.