Mechanism traditional Chinese medicine extract preventing and treating hepatocellular carcinoma by targeting the adenosine monophosphate-activated protein kinase signaling pathway
- VernacularTitle:中药提取物靶向腺苷酸活化蛋白激酶信号通路防治肝细胞癌的作用机制
- Author:
Shuo ZENG
1
;
Suqin HU
2
;
Yang HU
1
;
Lei LUO
2
;
Mingyan LI
2
;
Qinsheng ZHANG
2
Author Information
- Publication Type:Review
- Keywords: Carcinoma， Hepatocellular; Drugs， Chinese Herbal; Signal Transduction; AMP-Activated Protein Kinases
- From: Journal of Clinical Hepatology 2025;41(10):2161-2167
- CountryChina
- Language:Chinese
- Abstract: Hepatocellular carcinoma （HCC） is one of the most common malignant tumors with high incidence and mortality rates worldwide， which brings a huge burden to the physical and mental health and socio-economic life of patients. The adenosine monophosphate-activated protein kinase （AMPK） signaling pathway serves as the regulatory center of cellular energy metabolism and is closely associated with the biological activities of HCC cells， including autophagy， apoptosis， and angiogenesis， and it has become a hot topic in current cancer research. Traditional Chinese medicine drugs are abundant in natural components such as flavonoids， alkaloids， and phenols and have the characteristics of multiple targets， pathways， components， and hierarchies. By targeting the AMPK signaling pathway， these components can be used alone or in combination with conventional antitumor therapies to exert an anti-tumor effect on HCC from various aspects. This article reviews and summarizes the extracts of traditional Chinese medicine that target the AMPK signaling pathway for the prevention and treatment of HCC， in order to provide a theoretical basis and a reference for the clinical application of traditional Chinese medicine in the treatment of HCC and the development of related drugs.
