Mechanism of radiotherapy resistance in hepatocellular carcinoma and related coping strategies
- VernacularTitle:肝细胞癌放射治疗抵抗的机制及应对策略
- Author:
Qinbo WANG
1
;
Shuhua LI
2
;
Hang SUN
2
;
Chuanxin WU
1
Author Information
- Publication Type:Review
- Keywords: Carcinoma， Hepatocellular; Radiotherapy Resistance; Therapeutics
- From: Journal of Clinical Hepatology 2025;41(10):2154-2160
- CountryChina
- Language:Chinese
- Abstract: Primary liver cancer is a malignant tumor with continuously rising incidence and mortality rates worldwide， imposing a heavy burden on patients and society， and hepatocellular carcinoma （HCC） is a common type of primary liver cancer. As one of the important treatment methods for HCC， radiotherapy can effectively control the local growth of tumors and alleviate symptoms in patients. However， radiotherapy resistance seriously affects the treatment effect and has become a major challenge in clinical treatment. Current research shows a complex mechanism of radiotherapy resistance in HCC， involving multiple factors such as abnormal activation of intracellular signaling pathways， changes in tumor microenvironment， and regulation of gene expression. Therefore， a series of strategies have been proposed to address radiotherapy resistance in clinical practice， including regulating cell signaling pathways， improving tumor microenvironment， and combining different treatment modalities， and such strategies have shown promising application prospects. This article reviews the research advances in the mechanism of radiotherapy resistance and related coping strategies， in order to provide new perspectives for future research on radiotherapy for HCC.
