Regulatory role of macrophage glycolysis in metabolic dysfunction-associated fatty liver disease

VernacularTitle:巨噬细胞糖酵解在代谢相关脂肪性肝病中的调控作用
Author: Jiahan CHANG ¹ ; Yujie CAI ¹ ; Yixin HOU ² ; Juqiang HAN ¹
Author Information

1. Department of Ambulatory Medicine， The Seventh Medical Center， General Hospital of PLA， Beijing 100700， China
2. Center of Integrative Medicine， Beijing Ditan Hospital， Capital Medical University， Beijing 100015， China
Publication Type:Review
Keywords: Metabolic Dysfunction-Associated Fatty Liver Disease; Macrophages; Glycolysis; Metabolic Reprogramming
From: Journal of Clinical Hepatology 2025;41(10):2130-2135
CountryChina
Language:Chinese
Abstract: Metabolic dysfunction-associated fatty liver disease （MAFLD） is a common chronic liver disease in clinical practice， and macrophages are directly involved in the development， progression， and prognosis of MAFLD. Studies have confirmed that glucose metabolic reprogramming in macrophages directly affects immune function， which in turn affects the local inflammatory environment of liver and hepatocyte metabolism. This article reviews the changes in glucose metabolism of macrophages and the corresponding key molecules in the pathogenesis of MAFLD， in order to provide new targets and strategies for the prevention and treatment of MAFLD in the future.