Efficacy of interferon in treatment of chronic hepatitis B and the synergistic mechanism of traditional Chinese medicine in toxicity reduction and efficacy enhancement： A study based on the theory of latent pathogens
- VernacularTitle:基于伏邪理论探讨干扰素治疗慢性乙型肝炎的疗效特点及中医药协同减毒增效机制
- Author:
Shizhong WANG
1
;
Runxiu ZHENG
1
;
Kewei SUN
2
Author Information
- Publication Type:Review
- Keywords: Hepatitis B， Chronic; Latent Pathogens; Interferons; Traditional Chinese Medicine Therapy
- From: Journal of Clinical Hepatology 2025;41(10):2125-2129
- CountryChina
- Language:Chinese
- Abstract: In the traditional theoretical system of traditional Chinese medicine， latent pathogenic factors deeply hiding in the liver and gallbladder of the Jueyin meridian are the core pathogenesis of chronic hepatitis B. Interferon can regulate immunity and eliminate viruses， and clinical cure can be achieved by penetrating and removing pathogenic factors and toxins. However， it often causes dizziness and confusion reactions in the initial stage of treatment， and long-term use can damage Qi-blood； furthermore， its therapeutic effect depends on the patient’s own vital Qi. When traditional Chinese medicine is used in combination with interferon， drug compatibility should be adjusted according to the dynamic changes of pathogenesis， which can reduce adverse reactions， enhance the therapeutic outcome， expand the applicable population of interferon， and improve the clinical symptoms of patients.
