Influencing factors for quality of life in patients with primary biliary cholangitis： A systematic review
- VernacularTitle:原发性胆汁性胆管炎患者生活质量影响因素的系统评价
- Author:
Yanqiu FANG
1
;
Gui JIA
1
;
Lina CUI
1
;
Yulong SHANG
1
;
Ying HAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Primary Biliary Cholangitis; Quality of Life; Root Cause Analysis; Systematic Review
- From: Journal of Clinical Hepatology 2025;41(10):2062-2067
- CountryChina
- Language:Chinese
- Abstract: ObjectiveTo investigate the core influencing factors for quality of life in patients with primary biliary cholangitis through a systematic review， and to provide an evidence-based basis for understanding such factors. MethodsThe databases including CNKI， Wanfang Data， CBM， VIP， PubMed， Embase， Web of Science， Ovid， Scopus， and Medline were searched for articles assessing the influencing factors for quality of life in patients with primary biliary cholangitis using PBC-40 scale published up to January 11， 2025. Quality assessment was conducted using the scale compiled by the Agency for Healthcare Research and Quality， and then a qualitative evaluation was performed for the basic situation of the studies included in the analysis. ResultsA total of 11 articles were included， and the results showed that age， sex， albumin， alkaline phosphatase， gamma-glutamyl transferase， direct bilirubin， total bilirubin， total bile acid， alanine aminotransferase， aspartate aminotransferase， body mass index， and high-density lipoprotein cholesterol were important influencing factors for quality of life in patients with primary biliary cholangitis. ConclusionInfluencing factors include demographic features， liver function parameters， and physical and metabolic indicators； however， due to the limited number of studies， more high-quality large-sample studies are needed in the future.
