Effect of lidocaine medicated plaster combined with pregabalin on patients with postherpetic neuralgia and the impact on serum pain mediators
10.12206/j.issn.2097-2024.202505036
- VernacularTitle:利多卡因凝胶贴膏联合普瑞巴林治疗带状疱疹后神经痛患者疗效及对血清疼痛介质的影响
- Author:
Xiaodan WANG
1
;
Wenjie LIU
1
;
Chang SONG
1
;
Wenxing DONG
1
;
Qian ZHAO
1
;
Xiaolong MA
1
Author Information
1. Department of Pharmacy, Beidaihe Rehabilitation and Recuperation Center of Joint Logistic Support Force, Qinhuangdao 066100, China.
- Publication Type:Medicine&Clinical
- Keywords:
postherpetic neuralgia;
lidocaine medicated plaster;
pregabalin;
pain mediator;
curative effect
- From:
Journal of Pharmaceutical Practice and Service
2025;43(11):572-576
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of lidocaine medicated plaster （LMP） combined with pregabalin （PGB） on patients with postherpetic neuralgia （PHN）, and the impact on serum pain mediators. Methods 108 PHN patients admitted in our hospital from January 2024 to December 2024 were selected and grouped according to the time point of receiving treatment, 54 PHN patients treated with PGB from January 2024 to June 2024 were included in the PGB group, and 54 PHN patients treated with LMP on top of the PGB group from July 2024 to December 2024 were included in the PGB+LMP group. Comparisons were made between the two groups in terms of pain score, serum pain mediator levels, dosage of PGB, and incidence of adverse reactions. Results After 4 weeks of treatment, both groups showed a decrease in Pain Rating Index scores （sensory score and affective score）, Present Pain Intensity score, Visual Analog Scale score, and total score. Meanwhile, above scores of the PGB+LMP group were lower than those of the PGB group （P<0.05）. After 4 weeks of treatment, the levels of substance P（SP） and neuropeptide Y （NPY） in both groups were lower than those before treatment, while serum 5-hydroxytryptamine （5-HT） levels were higher than those before treatment. Moreover, the levels of SP and NPY were lower, and 5-HT level was higher in the PGB+LMP group than in the PGB group （P<0.05）. The dosages of PGB in the PGB+LMP group at T1, T, T3 and T4 were significantly lower than those in the PGB group （P<0.05）. The incidence of adverse reactions was 1.85%（1/54） in the PGB+LMP group. Compared to 5.56%（3/54） in the PGB group, and the difference was not statistically significant （P>0.05）. Conclusion LMP combined with PGB was effective in the treatment of patients with PHN, which could effectively alleviate pain and lower the levels of serum pain mediators, with good safety.
