Study on the quality and in vitro drug release behavior of sirolimus self-microemulsion-mesoporous silicon sustained release tablets
10.12206/j.issn.2097-2024.202402031
- VernacularTitle:西罗莫司自微乳-介孔硅缓释片的质量及体外释药行为考察
- Author:
Wenting HUANG
1
;
Zhihong LIU
1
;
Aiwen HUANG
1
;
Minxin ZHANG
1
;
Hongtao SONG
1
Author Information
1. The 900th Hospital of Joint Logistic Support Force, Fuzhou 350025, China.
- Publication Type:Originalarticles
- Keywords:
sirolimus;
self-microemulsion;
mesoporous silicon;
sustained-release tablet;
release behavior in vitro
- From:
Journal of Pharmaceutical Practice and Service
2025;43(11):560-563
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the quality and in vitro release behavior of the sirolimus self-microemulsion-mesoporous silicon sustained release tablets and provide a basis for further research and development of related preparations. Methods The hardness, brittleness and content uniformity of the sustained-release tablets were tested refer to Pharmacopoeia of the People’s Republic of China 2020. Different diameters （10, 11, 12 mm）, different hardness （50, 70, 90 N）, different speed （50, 75, 100 r/min）, different dissolution methods （pulp method, basket method） were investigated. The release conditions of the sustained-release tablets with different pH solution （distilled water solution and 0.4% SDS solution with pH of 1.2, 4.5 and 6.8, respectively） and the in vitro release conditions of the sustained-release tablets were observed. Results The hardness, brittleness and content uniformity of the self-made sustained-release tablets were qualified; different diameters and dissolution methods had no effect on the drug release behavior of the sustained-release tablets in vitro, while the different hardness, different rotational speed and the different pH release media had certain effects. Conclusion The sirolimus self-microemulsion-mesoporous silicon sustained release tablets had good sustained-release effect in vitro and was deserved to further study.
