Clinical and MRI Characteristics of Lymphomatosis Cerebri
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2021.0420
- VernacularTitle:大脑淋巴瘤病的临床及MRI特点分析
- Author:
Zhi-jie CHEN
1
;
Zhen-chao HUANG
1
;
En-peng SONG
1
;
Da-yang HUI
2
;
Chang ZHAO
2
;
Wei QIU
3
;
De-hong LU
4
;
Feng QIN
1
Author Information
1. Department of Neurosurgery， Lingnan Hospital of the Third Affiliated Hospital of Sun Yat-sen University， Guangzhou 510530， China
2. Department of Pathology， Third Affiliated Hospital of Sun Yat-sen University， Guangzhou 510530， China
3. Department of Neurology， Third Affiliated Hospital of Sun Yat-sen University， Guangzhou 510530， China
4. Department of Pathology， Xuanwu Hospital of Capital Medical University， Beijing 100053，China
- Publication Type:Journal Article
- Keywords:
primary central nervous system lymphomas;
lymphomatosis cerebri;
stereotactic surgery;
brain biopsy
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(4):628-634
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveLymphomatosis cerebri （LC） is a very rare variant of central nervous system lymphoma （PCNSL）. However， there are few reports at present and LC has worse prognosis than other types of PCNSL. Hence， this study reports 3 cases of LC whose pathologic features had been clarified through stereotactic brain biopsy， to better characterize LC in order to improve early diagnosis and treatment. MethodsFrom January 2017 to July 2020， the clinical manifestations， imaging and neuropathology of 3 patients diagnosed with LC in Lingnan Hospital of the Third Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed. ResultsThe 3 patients were 44-year-old， 61-year-old， and 64-year-old males with neurological dysfunction such as progressive cognitive decline， blurred vision， and lower limb weakness. Magnetic resonance imaging （MRI） revealed diffuse white matter lesions in the bilateral brain， which were manifested as long T1 and long T2 signal and demonstrated increased signal intensity on T2-fluid attenuated inversion recovery （T2-FLAIR） sequences and slightly higher in diffusion weighted imaging （DWI）. Stereotactic brain biopsy specimen showed diffuse B cells infiltration， CD20 （+）， consistent with LC. ConclusionsLC is a rare variant of central nervous system lymphoma that usually has no specific clinical performance， so the doctor can easily succumb to misdiagnosis and missed diagnosis. MRI evidence of bilateral hemispheric involvement should be alerts for this diagnosis. Brain biopsy should be early performed to clarify the pathology， which is of great significance for early diagnosis and prognosis.
