Independent Risk Factors of Pregnancy Failure in Patients with Fresh Single Blastocyst Transfer and GnRH-ant Protocol
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2021.0416
- VernacularTitle:拮抗剂方案新鲜单囊胚移植患者妊娠失败的独立危险因素分析
- Author:
Wen ZHOU
1
;
Yu-liang LIU
2
;
Tao LI
1
;
Wei-jie XING
1
;
Xi-ya ZHANG
1
;
Jian-ping OU
1
Author Information
1. Reproductive Medicine Center，The Third Affiliated Hospital of Sun Yat-sen University，Guangzhou 510630，China
2. Center for Reproductive Medicine，The First Affiliated Hospital of Sun Yat-sen University，Guangzhou 510058，China
- Publication Type:Journal Article
- Keywords:
single blastocyst transfer;
gonadotropin-releasing hormone antagonist/GnRH-ant;
in vitro fertilization-embryo transfer/IVF-ET;
trophectoderm;
intracytoplasmic sperm injection/ICSI
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(4):596-602
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore independent risk factors of pregnancy failure in patients with fresh single blastocyst and GnRH-ant protocol. MethodsData from 325 IVF treatment cycles performed at the Reproductive Medicine Center of the Third Affiliated Hospital of Sun Yat-sen University from January 2017 to April 2020 were retrospectively analyzed. Patients were assigned to clinical pregnant group （172 cycles） or non-pregnant group （153 cycles）. The basic information，stimulation characteristics，embryo development，the degree of blastocoele expansion，the grades of inner cell mass （ICM） and trophectoderm （TE） of the transferred blastocyst were compared. The variables with P < 0.1 were included in the logistic regression equation to detect independent risk factors affecting the clinical pregnancy rate. ResultsThe basic characteristics of patients were not significantly different between pregnant and non-pregnant group. However， the duration of Gn application（8.9±1.3 vs. 8.6±1.2），FSH level on HCG trigger day（12.1±3.7 vs. 13.0±4.0）U/L， fertilization method， the grades of ICM and TE of the transferred blastocyst were statistically different between the two groups. When infertility type， fertilization method， duration of Gn， FSH level on HCG trigger day， LH level on HCG trigger day， the grades of ICM and TE of transferred blastocyst were included in the regression model， the independent influence factors were the trophectoderm score of transferred blastocysts ［P=0.001，OR=2.173，95%CI：（1.359，3.476）， duration of Gn use ［P=0.015，OR=0.794，95%CI：（0.659，0.955）］ and fertilization method ［P=0.024，OR=2.065，95%CI：（1.098，3.882）］. ConclusionOur results suggest that poor trophectoderm score， shorter Gn using time and ICSI fertilization method are independent risk factors of clinical pregnancy failure in patients ≤ 40 years old with fresh single blastocyst transfer and GnRH-ant protocol.
