Changes in FT3， FT4 and TSH Levels in 3~21-day-old Preterm Infants Born at 28~36 Weeks of Gestation
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2021.0414
- VernacularTitle:28~36周早产儿生后3~21天血FT3、FT4、TSH变化分析
- Author:
Ben-yu TANG
1
;
Lei GUO
1
;
Dan-chun CHEN
2
;
Qun DAI
1
;
Yin-ya LI
1
;
Juan LIN
1
;
Shun-ye ZHU
1
Author Information
1. Department of Pediatrics，The Third Affiliated Hospital of Sun Yat-sen University， Guangzhou 510630， China
2. Department of Pediatrics，Guangzhou Women and Children’s Medical Center， Guangzhou 510620， China
- Publication Type:Journal Article
- Keywords:
preterm infants;
free triiodothyronine （FT3）;
free thyroxin （FT4）;
thyroid-stimulating hormone （TSH）
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(4):581-588
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the changes of serum levels of free triiodothyronine （FT3）， free thyroxin （FT4） and thyroid-stimulating hormone （TSH） in 3~21-day-old preterm infants born between 28 and 36 weeks of gestation. MethodsWe retrospectively reviewed the clinical data of 236 preterm infants born at 28~36 weeks of gestation in the third affiliated hospital of Sun Yat-sen university between July 2018 and June 2019. The clinical data included thyroid function parameters （FT3， FT4， TSH）， gestational age， gender， birth weight， birth length， time of examination， mode of conception， singleton or multiple birth， maternal thyroid disease and maternal gestational diabetes mellitus （GDM）. FT3， FT4 and TSH levels between 3~7-day-old and 8~21-day-old preterm infants were compared. Multiple linear regression models were used to identify the independent factors affecting FT3， FT4 and TSH levels. FT3 and FT4 levels in different gestational age groups were compared. ResultsCompared with those in 8~21-day-old preterm infants， in 3~7-day-old preterm infants， FT3 levels were significantly lower ［（3.23±0.54） pmol/L vs. （3.41±0.76） pmol/L， P=0.040］ and FT4 levels were significantly higher ［（15.36±3.40） pmol/L vs. （13.20±2.63） pmol/L， P＜0.001）］. No statistical difference was found in TSH levels. （P=0.846）. In 3~7-day-old preterm infants， FT3 levels were associated with gestational age （P < 0.001）； FT4 levels were associated with gestational age and time of examination （P < 0.001）. In 8~21-day-old preterm infants， both FT3 and FT4 levels were associated with gestational age and gender （P < 0.001， P < 0.001）. FT3 and FT4 were positively correlated with gestational age in both groups （P < 0.001， P < 0.001； P < 0.001， P = 0.001）. ConclusionGestational age affects the thyroid function of the preterm infants of 3~21 days. The younger the gestational age， the lower FT3 and FT4 levels. A reference range of FT4 or T4 related to gestational age should be established， combined with TSH， to evaluate the thyroid function in preterm infants.
