Association Between Telomere Length of Peripheral Blood Leukocytes and Chronic Heart Failure
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2021.0411
- VernacularTitle:慢性心力衰竭与外周血白细胞端粒长度的相关性
- Author:
Xiu-li ZHANG
1
;
Zhi-ye WU
1
;
Qiu-shi WANG
2
;
Fei MIAO
1
;
He-kai LI
1
;
Min-sheng CHEN
1
Author Information
1. Department of Cardiology// Laboratory of Heart Center，Zhujiang Hospital，Southern Medical University， Guangzhou 510280， China
2. Department of Cardiology， Beijing Friendship Hospital， Capital Medical University，Beijing 100050， China
- Publication Type:Journal Article
- Keywords:
leukocyte;
telomere;
telomere length;
chronic heart failure
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2021;42(4):557-562
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the association between telomere length of leukocytes and chronic heart failure （CHF）. MethodsA total of 224 patients were recruited in this study. The patients were divided into non-CHF （Non-CHF） group （involving 117 patients） and CHF group （involving 107 patients） according to left ventricular ejection fraction. Telomere length of peripheral blood leukocytes was measured by real-time fluorescence quantitative polynucleotide chain reaction （qPCR）. Telomere length of leukocytes was compared between Non-CHF group and CHF group. Binary Logistic regression model was used to analyze the association between telomere length and CHF. ResultsTelomere length in Non-CHF patients and CHF patients was 0.9（0.64~1.18）， 0.7（0.53~0.89）， respectively. Telomere length was shorter in CHF patients than in Non-CHF patients （P<0.001）. Further results showed that telomere length was associated with CHF ［OR=0.17， 95% CI was （0.07， 0.40）， P<0.05］. After adjusting confounding factors， telomere length was still associated with CHF ［OR=0.14， 95% CI was （ 0.05， 0.33）， P<0.05］. ConclusionThe results show that telomere length of peripheral blood leukocytes is independently associated with CHF.
