Role and molecular mechanism of angiotensin-converting enzyme inhibitor in rehabilitation after cerebral hemorrhage
10.19845/j.cnki.zfysjjbzz.2025.0169
- VernacularTitle:血管紧张素转化酶抑制剂在脑出血后康复中的作用及其分子机制研究
- Author:
Min ZHANG
1
;
Qiang WANG
1
Author Information
1. The Second People's Hospital of Hengshui， Hengshui 053000， China
- Publication Type:Journal Article
- Keywords:
Cerebral hemorrhage;
Angiotensin-converting enzyme inhibitor;
Neuroprotection;
Molecular mechanisms
- MeSH:
Neuroprotection
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(10):916-921
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role and molecular mechanism of angiotensin-converting enzyme inhibitor （ACEI） in rehabilitation after cerebral hemorrhage through a comparative analysis with a control group. Methods A total of 50 patients with cerebral hemorrhage were divided into observation group and control group for comparison. The patients in the observation group received ACEI treatment， while those in the control group received conventional treatment. The two groups were compared in terms of neurological function， brain imaging findings， blood biochemical parameters， and molecular mechanism indicators. Results At the beginning of treatment， there were no significant differences in the above indicators between the observation group and the control group. During the treatment process， the observation group showed significant advantages in neurological function assessment， brain imaging findings， and blood biochemical parameters. Compared with the control group after 1 week of treatment， the observation group had significantly lower neurological function score， absorption rate of cerebral hemorrhagic foci， blood pressure， blood glucose， and blood lipids （P<0.001）. Molecular mechanism indicators showed that compared with the control group， the observation group had significantly lower levels of angiotensin Ⅱ， neuroinflammatory factors， and neuronal apoptosis-related proteins （P<0.001）. Conclusion ACEI significantly promotes rehabilitation after cerebral hemorrhage and can improve neurological function， promote the absorption of cerebral hemorrhagic foci， and regulate blood pressure and the metabolism of blood glucose and blood lipids， and meanwhile，ACEI can exert a neuroprotective effect through multiple molecular mechanisms. Therefore， ACEI may become one of the effective drugs for the rehabilitation of cerebral hemorrhage.
- Full text:2025122916034336145血管紧张素转化酶抑制剂在脑出血后康复中的作用及其分子机制研究.pdf
