Role of gut microbiota dysbiosis in narcolepsy type 1
10.19845/j.cnki.zfysjjbzz.2025.0164
- VernacularTitle:肠道菌群失调在Ⅰ型发作性睡病中的作用
- Author:
Qian ZHAO
1
;
Hongju ZHANG
1
Author Information
1. People's Hospital of Henan University， Henan Provincial People's Hospital， Zhengzhou 450002， China
- Publication Type:Journal Article
- Keywords:
Narcolepsy;
Excessive daytime sleepiness;
Cataplexy;
Gut microbiota;
Microbiota-gut-brain axis
- MeSH:
Narcolepsy
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(10):886-889
- CountryChina
- Language:Chinese
-
Abstract:
Narcolepsy （NP） is a rare nervous system disease with the typical symptoms of excessive daytime sleepiness， cataplexy， sleep paralysis， and hypnagogic hallucination. The pathophysiological mechanism of NP remains unclear， and it is currently believed that NP is an immune-related disease closely associated with HLA-DQB1*06∶02 genotype and it can be triggered by environmental factors such as infection and vaccination， while the precise neural pathways leading to degeneration/apoptosis of orexin neurons in the lateral hypothalamic area remain unknown. In recent years， an increasing number of evidence has revealed the association between sleep disturbance and gut microbiota， and in particular， the microbiota-gut-brain axis plays an important role in sleep regulation. This article systematically reviews the regulatory mechanism of gut microbiota in the central nervous system and discusses the potential interaction between gut microbiota and NP， in order to provide new perspectives for both mechanistic research and clinical management of NP.
- Full text:2025122914124583180肠道菌群失调在Ⅰ型发作性睡病中的作用.pdf
