Clinical efficacy of transcranial alternating current stimulation combined with pharmacotherapy in treatment of chronic insomnia
10.19845/j.cnki.zfysjjbzz.2025.0163
- VernacularTitle:经颅交流电刺激联合药物治疗慢性失眠的临床研究
- Author:
Mengmeng QI
1
;
Xinrong WU
2
Author Information
1. 郑州大学附属郑州中心医院神经内科，河南 郑州 450000
2. 上海交通大学医学院附属瑞金医院神经内科，上海 200025
- Publication Type:Journal Article
- Keywords:
Chronic insomnia;
Transcranial alternating current stimulation;
Anxiety and depression;
Cognitive function
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(10):882-885
- CountryChina
- Language:Chinese
-
Abstract:
Objective Most patients with chronic insomnia depend on long-term medication， which may easily lead to a poor treatment outcome and adverse drug reactions， and transcranial alternating current stimulation （tACS）， as a noninvasive neuromodulation technique， can improve chronic insomnia. This study aims to investigate the clinical efficacy of tACS combined with pharmacotherapy in the treatment of chronic insomnia. Methods A total of 46 patients with chronic insomnia were enrolled and randomly divided into pharmacotherapy group with 20 patients and pharmacotherapy+tACS treatment group with 26 patients. The tACS electrodes were attached to the frontal region and the bilateral mastoids， with a frequency of 77.5 Hz and a current intensity of 15 mA， for 40 minutes each time， once a day for 10 consecutive days. The primary outcome measures were Pittsburgh Sleep Quality Index （PSQI） score and its improvement rate after 4 weeks， and the secondary outcome measures included the scores of Hamilton Depression Rating Scale （HAMD）， Hamilton Anxiety Rating Scale （HAMA）， Mini-Mental State Examination （MMSE）， and Montreal Cognitive Assessment （MoCA） and their improvement rates. Results Compared with the pharmacotherapy group， the pharmacotherapy+tACS treatment group had a significant reduction in PSQI score （P<0.05）， with an improvement rate of 37% and 21%， respectively， suggesting that the combined therapy had a better effect in improving sleep quality. The pharmacotherapy+tACS treatment group also had reductions in HAMA and HAMD scores， suggesting improvements in anxiety and depression symptoms， and there were no significant differences in MMSE and MoCA scores between the two groups. Conclusion Pharmacotherapy combined with tACS has a better effect than pharmacotherapy alone in improving sleep quality and anxiety and depression symptoms in patients with chronic insomnia， and therefore， it has good application prospects in clinical practice.
- Full text:2025122913301014172经颅交流电刺激联合药物治疗慢性失眠的临床研究.pdf
