The pathological association between mitochondrial dysfunction and sleep disorders
10.19845/j.cnki.zfysjjbzz.2025.0193
- VernacularTitle:线粒体异常与睡眠障碍疾病的病理关系
- Author:
Jiaqi CAI
1
Author Information
1. Department of Urology， The 983 Hospital of PLA Joint Logistic Support Force， Tianjin 300143， China
- Publication Type:Journal Article
- Keywords:
Mitochondrial function;
Sleep disorders;
Oxidative stress;
Energy metabolism disorder;
Neuroinflammation;
Antioxidant intervention
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(11):1053-1056
- CountryChina
- Language:Chinese
-
Abstract:
Through a systematic review of the articles on the association between mitochondrial function and sleep disorders in recent years， this article discusses the central role and pathological mechanisms of mitochondrial dysfunction in the pathogenesis and development of various sleep disorders. Mitochondrial dysfunction participates in the pathological processes of sleep disorders through various mechanisms： intermittent hypoxia in obstructive sleep apnea leads to excessive production of reactive oxygen species （ROS）， oxidative stress， and mitochondrial damage， thereby affecting energy metabolism and neurological function； abnormalities in dopamine synthesis and iron metabolism in restless legs syndrome/periodic limb movement disorder are closely associated with insufficient mitochondrial ATP production； sleep disturbances associated with neurodegenerative diseases （e.g.， Alzheimer disease） often involve significant mitochondrial functional defects and form a vicious cycle with circadian rhythm disruption； the core mechanisms of persistent fatigue and sleep disturbances in chronic fatigue syndrome involve inadequate mitochondrial ATP generation， the increase in oxidative stress， and imbalance in neurotransmitters； mitochondria help maintain the stability of circadian rhythm through energy supply， ROS regulation， and metabolic pathways，and mitochondrial dysfunction can disrupt the biological clock； sleep deprivation itself can impair mitochondrial function，leading to abnormal energy metabolism， oxidative stress， DNA damage， and neuroinflammation；neuroinflammation and mitochondrial dysfunction form a bidirectional vicious cycle in neurodegenerative sleep disorders.Mitochondrial dysfunction involves the key pathological links such as impaired energy metabolism， oxidative stress，neuroinflammation， and circadian rhythm dysregulation in the development and progression of various sleep disorders.Targeted protection of mitochondrial function and alleviation of oxidative stress and neuroinflammation are expected to become new strategies for improving various sleep disorders and delaying disease progression.
- Full text:2025122911235289627线粒体异常与睡眠障碍疾病的病理关系.pdf
