Changes in the serum levels of visinin-like protein 1 and fibrinogen-like protein 2 and their correlation with the degree of neurological deficits and prognosis in patients with acute cerebral hemorrhage
10.19845/j.cnki.zfysjjbzz.2025.0188
- VernacularTitle:急性脑出血患者血清VILIP-1、FGL2水平变化及其与神经功能缺损程度和预后的关系
- Author:
Yingjie YANG
1
;
Gongling WEN
1
Author Information
1. Department of Neurology， Nanyang Central Hospital， Nanyang 473000， China
- Publication Type:Journal Article
- Keywords:
Acute cerebral hemorrhage;
Serum visinin-like protein 1;
Serum fibrinogen-like protein 2;
Neurological function;
Prognosis
- MeSH:
Prognosis
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(11):1029-1033
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in the serum levels of visinin-like protein 1 （VILIP-1） and fibrinogen-like protein 2（FGL2） and their correlation with the degree of neurological deficits and prognosis in patients with acute cerebral hemorrhage. Methods A total of 121 patients with acute cerebral hemorrhage who received treatment in our hospital were enrolled as observation group， and 121 individuals who underwent physical examination during the same period of time were enrolled as control group. The serum levels of VILIP-1 and FGL2 were measured， and their correlation with the degree of neurological deficits was analyzed； a logistic regression analysis was used to investigate the influencing factors for poor prognosis in patients with acute cerebral hemorrhage；the value of the serum levels of VILIP-1 and FGL2 in predicting the prognosis of patients with acute cerebral hemorrhage was analyzed. Results The observation group had significantly higher serum levels of VILIP-1 and FGL2 than the control group（P<0.05），and the serum levels of VILIP-1 and FGL2 were positively correlated with the neurological function of patients（P<0.05）.Compared with the good prognosis group， the poor prognosis group had significantly higher proportion of patients with hyperglycemia， serum levels of VILIP-1 and FGL2， and NHISS score （P<0.05）. Serum VILIP-1 and FGL2 were independent risk factors for poor prognosis in patients with acute cerebral hemorrhage （P<0.05），and the combination of serum VILIP-1 and FGL2 had a higher predictive value than each indicator alone （P<0.05）. Conclusion There are increases in the serum levels of VILIP-1 and FGL2 in patients with acute cerebral hemorrhage， which are positively correlated with neurological function and are risk factors for poor prognosis in patients with acute cerebral hemorrhage， and the combination of the two indicators has a higher predictive value for the prognosis of patients with acute cerebral hemorrhage.
- Full text:2025122911020218190急性脑出血患者血清VILIP-1、FGL2水平变化及其与神经功能缺损程度和预后的关系.pdf
