Clinical features and echocardiographic changes of cryptogenic perforator infarction patients with patent foramen ovale
10.19845/j.cnki.zfysjjbzz.2025.0185
- VernacularTitle:卵圆孔未闭相关隐源性卒中穿支动脉梗死患者的临床特征及超声心动图改变
- Author:
Hui ZHANG
1
;
Wenjie CAO
2
Author Information
1. 复旦大学附属华山医院神经内科， 上海 200040
2. 复旦大学附属华山医院神经内科， 上海 200040;复旦大学医学神经生物学国家重点实验室， 上海 200032;复旦大学附属华山医院国家老年疾病临床医学研究中心， 上海 200040
- Publication Type:Journal Article
- Keywords:
Transthoracic echocardiography;
Cryptogenic stroke;
Perforator infarction;
Patent foramen ovale
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(11):1012-1016
- CountryChina
- Language:Chinese
-
Abstract:
Objective We sought to investigate the clinical characteristics and echocardiographic changes of cryptogenic perforator infarction（PI） patient with patent foramen ovale（PFO）. Methods From Jan 2015 to Dec 2023， patients diagnosed with cryptogenic stroke were retrospectively included in our study. All patients received transthoracic echocardiography（TTE） and transcranial Doppler（TCD）.PFO was diagnosed by the bubble test of TCD. Comparisons of clinical features and TTE findings were performed firstly in PI patients， between PFO and non-PFO， and then in patients with PFO， between PI and cortical infarction（CI）. Results A total of 251 patients were retrospectively analyzed. PFO was detected in 104 patients，of those，40.4%（42/104） had pure PI（PFO-PI） and 59.6%（62/104） had CI（PFO-CI）. In patients without PFO，30.6%（45/147） had pure PI（non-PFO-PI）.Compared with non-PFO-PI， PFO-PI associated with a higher proportion of vertebrobasilar circulation infarctions（VCI）（47.6% vs 17.8%， P=0.003）， lower mean value of left ventricle end-diastolic diameters（LVEDd）（47.3 mm vs 49.8 mm， P=0.037） and lower peak E-wave velocity（62.6 cm/s vs 70.8 cm/s，P=0.015）.In PFO patients， PFO-PI was detected with a lower mean value of aorta root diameters（32.5 mm，P=0.011） and lower mean value of LVEDd（47.3 mm，P=0.045） than PFO-CI（34.5 mm and 49.4 mm， respectively）. Conclusion Higher proportion of VCI was found in PFO-PI. Lower LVEDd， lower Em and without aortic root dilatation were three echocardiographic features associated with PFO-PI in cryogenic PI patients.
- Full text:2025122910382295376卵圆孔未闭相关隐源性卒中穿支动脉梗死患者的临床特征及超声心动图改变.pdf
