Application of ultrasonic measurement of optic nerve sheath diameter in assessing brain death
10.19845/j.cnki.zfysjjbzz.2025.0176
- VernacularTitle:超声测量视神经鞘直径在脑死亡中的应用
- Author:
Liyang BAI
1
;
Xiaodan LI
2
;
Cong LI
1
;
Lijuan WANG
1
Author Information
1. 吉林大学白求恩第一医院神经内科， 吉林 长春 130021
2. 四平市中心人民医院超声科， 吉林 四平 136000
- Publication Type:Journal Article
- Keywords:
Brain death;
Optic nerve sheath diameter;
Noninvasive measurement
- From:
Journal of Apoplexy and Nervous Diseases
2025;42(11):963-967
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of ultrasound measurement of optic nerve sheath diameter （ONSD） in the assessment of brain death. Methods A total of 124 subjects were enrolled and divided into brain death group with 34 patients， deep coma group with 28 patients， and healthy control group with 62 individuals， and ultrasound measurement of ONSD was performed for all three groups. A Spearman correlation analysis was used to investigate the correlation of brain death with ONSD and baseline characteristics. Univariate and multivariate Logistic regression analyses were used to identify the independent predictive value of ONSD for brain death. The receiver operating characteristic （ROC） curve was plotted to determine the optimal cut-off value of ONSD and evaluate its diagnostic efficacy. Results The Spearman correlation analysis showed a significant positive correlation between brain death and ONSD （r=0.825，P<0.001）. The multivariate Logistic regression analysis confirmed that ONSD was an independent predictive factor for brain death （odds ratio=70.874， P<0.05，Nagelkerke R2=0.739， Hosmer-Lemeshow test P=0.786）.ONSD had an area under the ROC curve （AUC） of 0.939（95%CI 88.3‒99.4） in the brain death group and the deep coma group， with an optimal cut-off value of 6.005 mm， a sensitivity of 97.1%，a specificity of 78.6%， a positive predictive value of 84.6%， and a negative predictive value of 95.7%. Conclusion Ultrasound measurement of ONSD has an important clinical application value in the assessment of brain death.
- Full text:2025122909364833663超声测量视神经鞘直径在脑死亡中的应用.pdf
