Results of PRP and hyaluronic acid treatment in rotator cuff tendon disorders
- VernacularTitle:Мөр эргүүлэгч шөрмөсний эмгэгүүдийн үед PRP болон гиалурин эмчилгээ хийсэн үр дүн
- Author:
Munkhdelger M
1
;
Baatarjav S
2
;
Munkhsaikhan T
3
;
Baasanjav N
4
Author Information
1. National Trauma and Orthopedic Research Center of Mongolia, Ach Medical University
2. National Trauma and Orthopedic Research Center of Mongolia; Ach Medical University
3. National Trauma and Orthopedic Research Center of Mongolia
4. Ach Medical University
- Publication Type:Journal Article
- Keywords:
Hyaluronic Acid;
Platelet-Rich Plasma;
Rotator Cuff;
Shoulder Pain;
Tendon Healing
- From:Mongolian Medical Sciences
2025;213(3):15-19
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Partial tears of the rotator cuff tendons are a common cause of shoulder pain and functional
limitation among adults. Conservative management often provides only partial relief in
chronic cases. Platelet-rich plasma (PRP) and hyaluronic acid (HA) injections have shown
promising effects in tendon regeneration, pain reduction, and improved function. PRP
delivers growth factors that promote healing and reduce inflammation, while HA maintains
tendon elasticity and inhibits inflammatory cytokines. Combining PRP and HA may produce
synergistic therapeutic effects; however, data on their combined use in Mongolian patients
remain limited.
Objective:To evaluate and compare the clinical outcomes of PRP, HA, and combined PRP + HA
injections in patients with rotator cuff tendon disorders.
Material and Method:Sixty patients diagnosed with rotator cuff pathology (ICD code M75.1) at the National Trauma
and Orthopedic Research Center of Mongolia between June 2024 and June 2025 were
enrolled. Participants were randomly divided into three groups: PRP + HA (n=20), PRP only
(n=20), and HA only (n=20). Each patient received three ultrasound-guided injections at two
week intervals. Clinical outcomes were assessed using pain score (VAS), range of motion
(ROM), Constant–Murley score, and the Shoulder Pain and Disability Index (SPADI) at
baseline, 4, 12, and 24 weeks. Data were analyzed using ANOVA, with p < 0.05 considered
significant.
Ethics Approval. “Ach” Medical University, Ethics Committee Resolution, Date: June 30,
2023 Resolution No: 23/02/12, Location: Ulaanbaatar, Mongolia
Results:The PRP+HA group demonstrated the greatest improvements across all parameters.
Pain decreased by 60% at 12 weeks, and ROM increased by 20–25% from baseline (p<0.05).
SPADI scores improved from 63.2 to 21.3 at 24 weeks (p < 0.001). No serious adverse
effects occurred.
Conclusion:Combined PRP and HA injections significantly enhance pain relief, mobility,
and shoulder function compared to either treatment alone. This combined therapy is safe,
effective, and represents a promising approach for managing rotator cuff tendon disorders.
- Full text:2025122317565151096MAUS-2025-213(3)-15-19.pdf
