A study on risk factors and causes influencing the outcomes of In Vitro Fertilization (IVF)
- VernacularTitle:Үр шилжүүлэн суулгах эмчилгээний үр дүнд нөлөөлөх зарим эрсдэлт хүчин зүйлс, шалтгааныг судалсан үр дүн
- Author:
Amarzaya L
1
;
Khadbaatar R
2
;
Gunjinlkham S
2
;
Khulan O
2
;
Erkhembaatar T
3
;
Jargalsaikhan B
4
Author Information
1. Mongolian National University of Medical Sciences;Unimed International Hospital
2. Unimed International Hospital
3. Urguu Maternity Hospital
4. Mongolian National University of Medical Sciences
- Publication Type:Journal Article
- Keywords:
AMH-Anti-Mullerian Hormone;
AFC-Antral Follicle Count;
IVF-In Vitro Fertilization;
Ovarian stimulation
- From:Mongolian Medical Sciences
2025;211(1):3-12
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Infertility is defined as the inability of couples to conceive despite engaging in regular,
unprotected sexual intercourse for over a year. Assisted reproductive technology (ART),
particularly in vitro fertilization (IVF), has emerged as the most widely utilized solution for
infertility. The cause of infertility, a woman’s ovarian reserve, response, egg and sperm quality,
the number and quality of embryos, and various other factors influence the outcome of IVF.
Despite significant advancements in ART, predicting IVF outcomes remains challenging,
especially when tailoring treatment strategies to individual patient factors.
Objective:To investigate the clinical indicators, ovarian reserve markers, and stimulation outcomes
influencing the success of IVF treatment in Mongolian women.
Material and Method:A prospective study was conducted at the Unimed International Hospital IVF Center between
October 2023 and August 2024. Clinical and demographic factors, ovarian reserve markers
(FSH, AMH, AFC), and ovarian stimulation outcomes were analyzed in 242 women aged 25
44 years undergoing IVF. Logistic regression analysis was performed to identify risk factors
and predictors of clinical pregnancy, with a statistical significance threshold set at p<0.05.
Results:Among 208 women who underwent embryo transfer, the clinical pregnancy rate was 36.5%,
and biochemical pregnancy was observed in 38.4%. Age was a significant predictor, with older
age groups (35-39 years: OR=7.11, p=0.004; 40-44 years: OR=12.65, p=0.004) associated with reduced IVF success. Ovarian reserve markers, including AMH (OR=8.92, p<0.001)
and AFC (OR=2.78, p<0.001), were significantly correlated with pregnancy outcomes,
whereas FSH was not significant (p=0.518). Higher numbers of pre-ovulatory follicles (POF)
(OR=1.03, p=0.040) and high-grade embryos (OR=1.26, p=0.045) increased the likelihood of
clinical pregnancy. No significant associations were observed between total gonadotrophin
dosage, ovarian sensitivity index, and fertilization rate with pregnancy outcomes.
Conclusion:Age and ovarian reserve markers (AMH, AFC) are critical predictors of IVF success, while pre
ovulatory follicle counts and number of high-grade embryos significantly enhance pregnancy
likelihood. These findings emphasize the importance of personalized ART protocols tailored
to ovarian reserve and age-related factors to optimize IVF outcomes.
- Full text:2025122317102478482MAUS-2025-211(1)-3-12.pdf
