Recent advances in platelet lipid rafts
10.13303/j.cjbt.issn.1004-549x.2025.10.019
- VernacularTitle:血小板脂筏最新研究进展
- Author:
Diyang WU
1
;
Lujie ZHOU
2
;
Zhicheng WANG
2
Author Information
1. Department of Blood Transfusion, Huzhou Central Hospital, Huzhou 313000, China
2. Department of Blood Transfusion, Huashan Hospital, Fudan University, Shanghai 20020, China
- Publication Type:Journal Article
- Keywords:
platelets;
lipid rafts;
signal transduction
- From:
Chinese Journal of Blood Transfusion
2025;38(10):1421-1426
- CountryChina
- Language:Chinese
-
Abstract:
Platelet lipid rafts are dynamic nanodomains enriched in cholesterol and sphingolipids within the plasma membrane. As pivotal hubs for signal transduction, membrane trafficking, and intercellular interactions, they have garnered significant attention in recent years for their roles in regulating platelet function and related disease mechanisms. This article reviews the structural characteristics and molecular composition of platelet lipid rafts, as well as their central roles in signal transduction and cytoskeletal reorganization. It particularly focuses on the functional abnormalities and pathological contributions of lipid rafts in diseases such as atherosclerosis, antiphospholipid antibody syndrome, and ANCA-associated vasculitis. Research indicates that lipid rafts coordinate platelet activation, inflammatory responses, and immunomodulatory processes by integrating receptor clustering, enrichment of signaling proteins, and regulation of metabolites. Finally, the article discusses the future prospects of lipid raft-targeted nanotherapeutic strategies and addresses challenges in translational research, providing a theoretical foundation and novel perspectives for understanding platelet biology and intervening in thrombo-inflammatory diseases.
