Characteristics of asymptomatic HBV infection in HBsAg-positive blood donors from Dalian
10.13303/j.cjbt.issn.1004-549x.2025.10.010
- VernacularTitle:大连地区HBsAg阳性献血者无症状HBV感染的特征分析
- Author:
Yingying WANG
1
;
Xuelian DENG
1
;
Xiaohan GUO
1
;
Huihui GAO
1
;
Peng SUN
1
;
Dan LIU
1
;
Daniel CANDOTTI
2
;
Bing WANG
3
Author Information
1. Dalian Blood Center, Dalian 116001, China
2. Department of Virology, INSERM U955, IMRB, AP-HP and University of Paris-Est, Henri Mondor Hospital, Créteil 94000, France
3. College of Basic Medical Sciences, Dalian Medicine University, Dalian 116044, China
- Publication Type:Journal Article
- Keywords:
asymptomatic HBV infection;
HBsAg-positive;
characteristics of infection;
blood donor
- From:
Chinese Journal of Blood Transfusion
2025;38(10):1361-1369
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze serological and molecular characteristics of asymptomatic HBV infection in HBV surface antigen positive (HBsAg+) blood donors from Dalian. Methods: The prevalence of HBsAg was analyzed among blood donors in Dalian between 2013 and 2022. Randomly selected HBsAg+ blood samples were subjected to HBV serological testing, HBV viral DNA quantification, and HBV genotyping. Results: Over this ten-year period, the prevalence of HBsAg decreased from 1.25% to 0.50% among blood donors in Dalian. Donors who tested positive for HBsAg prior to donation using a rapid test (RT) accounted for 92.5% of all HBsAg+ donors identified. A total of 240 confirmed HBsAg+ blood donors were randomly selected, including 125 donors with positive results and 115 with negative results in the pre-donation rapid test. HBsAg+ donors were mainly males (71.2%), with a median age of 42, and 97.5% of them being first-time donors. Based on HBV serological profiles, three stages of infection were identified: early infection (2.9%), suspected acute hepatitis (0.8%), and chronic infection (96.3%). The dominant HBV genotypes were C (68.9%) and B (28.4%). Among chronic HBV infection individuals, donors infected with HBV genotype B were older than those infected with genotype C (median age: 45y vs 38.5y, P<0.05). Additionally, they showed significantly lower HBsAg levels with a narrower distribution range than those infected with genotype C [median: 23.2 IU/mL (range: <0.05-7 910 IU/mL) vs 968 IU/mL (range: <0.05-3.4×10
), P<0.05]. However, no significant difference was observed in the HBV DNA loads between these two genotypes (P>0.05). Conclusion: Between 2013 and 2022, the prevalence of HBsAg among blood donors in Dalian showed a year-over-year decline. Chronic infection was predominant among HBsAg+ first-time blood donors. The characteristics of chronic infection in blood donors differed significantly depending on the viral genotype, manifesting as differences in age of infected individuals and HBsAg level distribution.
