Clinical study on the application of universal red blood cells in emergency treatment for patients with hemorrhagic shock
10.13303/j.cjbt.issn.1004-549x.2025.10.004
- VernacularTitle:通用型红细胞紧急抢救失血性休克患者的临床应用研究
- Author:
Jinqi LI
1
;
Mei ZHOU
1
;
Xingyi WANG
1
;
Rui ZHANG
1
;
Yan ZANG
1
;
Zhanshan CHA
1
;
Bao hua QIAN
1
;
Haihui GU
1
Author Information
1. Department of Blood Transfusion, the First Affiliated Hospital of Naval Military Medical University, Shanghai 200433, China
- Publication Type:Journal Article
- Keywords:
trauma;
universal red blood cell;
shock index;
emergency treatment
- From:
Chinese Journal of Blood Transfusion
2025;38(10):1320-1326
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the safety and efficacy of the emergency infusion protocol for universal red blood cells by analyzing its clinical application in patients treated at our hospital's war trauma and emergency center. Methods: Data were collected from 133 patients who received universal red blood cell transfusion in the war trauma center of our hospital from January 2016 to December 2024. The basic information, universal red blood cell transfusion volume, compatible blood components, transfusion volume, blood routine (Hb, Hct), liver and kidney function (ALT, AST, TBil, DBil, creatinine, etc.) and coagulation function (PT, APTT, Fib, etc.) before and after transfusion were retrospectively analyzed. Results: Among the 133 patients who received a total of 374 units of universal red blood cells, the 24-hour survival rate was 62.4% (83/133). Spearman correlation analysis showed a positive correlation between shock index and universal red blood cell transfusion volume (r=0.283, P<0.05). Patients were stratified by universal red blood cell transfusion volume (≤ 3 U vs ≥ 4 U). The low volume group had less homotypic red blood cell transfusion volume and total transfusion volume at different time points, and the difference was statistically significant: within 2 h [2(2, 4)vs 4(3, 7), P=0.033<0.05], 0~24 h [6(4, 9) vs 8(6, 14), P=0.028<0.05], total transfusion volume [13(8, 20)vs 19(12, 35), P=0.021<0.05]. No acute hemolytic transfusion reaction occurred within 24 hours after transfusion of universal red blood cell. Conclusion: Universal red blood cells are safe for use in emergency treatment. Furthermore, the shock index combined with the volume of universal red blood cells transfused can predict subsequent transfusion requirements and enables the early reservation of compatible blood, thereby preventing delayed resuscitation.
