Introduction and enlightenment of the Recommendations and Expert Consensus for What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia Expertise Initiative-Control/Avoidance of Bleeding
10.13303/j.cjbt.issn.1004-549x.2025.11.024
- VernacularTitle:《儿科重症监护输血和贫血专家倡议：指导危重患儿血小板或血浆输注的实验室检测和生理指标以及不同类型血液成分的附加特殊属性》介绍及其启示
- Author:
Xionghui ZHOU
1
;
Jiaohui ZENG
1
;
Hao TANG
1
;
Lan GU
1
;
Zhi LIN
2
;
Dan WANG
2
;
Mingyi ZHAO
2
;
Minghua YANG
2
;
Rong GUI
1
;
Rong HUANG
1
;
Junhua ZHANG
1
Author Information
1. Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, China
2. Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha 410013, China
- Publication Type:Journal Article
- Keywords:
child;
coagulopathy;
critical illness;
hemostasis;
plasma;
platelet transfusion
- From:
Chinese Journal of Blood Transfusion
2025;38(11):1641-1649
- CountryChina
- Language:Chinese
-
Abstract:
Based on systematic review and consensus meetings of international multidisciplinary experts, the Transfusion and Anemia Expert Initiative—Control/Avoidance of Bleeding (TAXI-CAB) project team developed management strategies for platelet and plasma transfusion in critically ill children. This consensus presents five expert consensus statements and two recommendations addressing two key questions: 1) What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically ill Children? 2) What Product Attributes Are Optimal to Guide Specific Product Selection? This consensus provides guidance for decision-making regarding plasma and platelet transfusion in critically ill children in two aspects: relevant laboratory testing indicators and additional special properties of blood components. This article explains the rationale behind the recommendations in this part of the guideline, aiming to emphasize the need for clinicians to develop transfusion strategies based on multidimensional assessment, while calling for enhanced interdisciplinary collaboration and evidence-based research to optimize blood management in critically ill children, reducing the risk of over-transfusion and improving treatment outcomes. Furthermore, there remains an urgent need for further research to explore laboratory indicators associated with bleeding risk to guide transfusion therapy.
