Research progress in occult hepatitis B virus infection and its transmission via blood transfusion
10.13303/j.cjbt.issn.1004-549x.2025.11.022
- VernacularTitle:隐匿性乙型肝炎病毒感染与输血传播研究进展
- Author:
Rui WANG
1
;
Bo WANG
2
;
Yang YU
1
Author Information
1. Department of Transfusion Medicine, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
2. The Southern Medical Branch of PLA General Hospital, Beijing 100071, China
- Publication Type:Journal Article
- Keywords:
occult hepatitis B virus infection (OBI);
cccDNA;
transfusion transmission
- From:
Chinese Journal of Blood Transfusion
2025;38(11):1627-1633
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the development of nucleic acid testing (NAT) have significantly reduced the risk of hepatitis B virus (HBV) transmission through blood transfusion. However, a residual risk persists. Occult hepatitis B virus infection (OBI), identified during blood donor screening, has become a growing concern for transfusion safety. This review summarizes the epidemiological characteristics, infection mechanism, traditional and novel diagnostic markers, risk factors for transfusion transmission, and assessments of residual risk of OBI, in order to provide reference for improving the quality of blood screening, reducing the risk of HBV transfusion transmission and ensuring the blood safety of blood donors.
