Research progress on the pathogenesis, prevention and treatment of immune platelet transfusion refractoriness
10.13303/j.cjbt.issn.1004-549x.2025.11.021
- VernacularTitle:免疫性血小板输注无效发生机制及防治措施研究进展
- Author:
Penghui LI
1
;
Chenggao WU
1
;
Aiping LE
1
Author Information
1. The First Affiliated Hospital of Nanchang University, Nanchang 330006, China; Key Laboratory of Jiangxi Province for Transfusion Medicine, Nanchang 330006, China
- Publication Type:Journal Article
- Keywords:
platelet transfusion refractoriness;
immune factors;
pathogenesis;
prevention and treatment measures
- From:
Chinese Journal of Blood Transfusion
2025;38(11):1620-1626
- CountryChina
- Language:Chinese
-
Abstract:
Platelet transfusion refractoriness (PTR) is one of the common problems in platelet transfusion, significantly impacting patient clinical outcomes and increasing the demand for allogeneic platelet transfusion. Both immune and non-immune factors contribute to PTR, among which the occurrence mechanism of immune platelet transfusion refractoriness (IPTR) involves humoral and cellular immune processes and is influenced by platelet storage, processing, and the patient's disease, therapy and immune status. This review comprehensively discusses the research related to the factors for alloimmune of IPTR, the mechanism of platelet clearance and its influencing factors. Furthermore, it explores feasible prevention and treatment measures such as platelet compatibility transfusion and clinical treatments. The aim is to provide a systematic cognition for a deeper understanding of the pathological process of platelet alloimmunization and clearance, and to provide a theoretical basis for the construction of precise clinical prevention and treatment strategies for IPTR, as well as to explore feasible research directions in this field in the future.
