Current research status on the inhibition of platelet activation by blood-activating and stasis-resolving traditional Chinese medicine
10.13303/j.cjbt.issn.1004-549x.2025.11.019
- VernacularTitle:活血化瘀中药抑制血小板活化的研究现状
- Author:
Wenqiu FENG
1
;
Ying HE
1
;
Peiyuan ZHU
1
Author Information
1. Department of Transfusion Medicine, Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210000, China
- Publication Type:Journal Article
- Keywords:
promoting blood circulation and resolving stasis;
traditional Chinese medicine (TCM);
platelet;
activation;
mechanism
- From:
Chinese Journal of Blood Transfusion
2025;38(11):1602-1610
- CountryChina
- Language:Chinese
-
Abstract:
Platelet activation plays a crucial role in the pathogenesis of cardiovascular and cerebrovascular diseases and the safety of platelet transfusion. Blood-activating and stasis-resolving Chinese herbs, known for improving blood circulation and eliminating blood stasis, can be classified into four categories: blood-activating and pain-relieving herbs, blood-activating and menstruation-regulating herbs, blood-activating and wound-healing herbs, and blood-breaking and mass-eliminating herbs. Modern research has revealed that these herbs exert antiplatelet activation effects through multiple molecular mechanisms. Key mechanisms include regulating the arachidonic acid metabolic pathway, inhibiting platelet membrane receptor function, influencing intracellular signal transduction, and modulating platelet-vascular endothelial interactions. Compared with conventional antiplatelet drugs, blood-activating and stasis-resolving Chinese herbs offer the advantage of multi-pathway synergistic effects and demonstrate potential value in prolonging platelet storage. This article systematically elaborates on the active monomers and mechanisms of these four categories of Chinese herbs in inhibiting platelet activation, summarizing their multi-target and multi-pathway characteristics, aiming to provide a theoretical basis for the clinical application of these herbs in suppressing platelet activation.
