Analysis of related indicators and interventions in apheresis platelet donors with low ferritin
10.13303/j.cjbt.issn.1004-549x.2025.11.017
- VernacularTitle:低铁蛋白单采血小板献血者相关指标和干预措施分析
- Author:
Jie PAN
1
;
Liang GUAN
1
;
Danhong WANG
1
;
Yunming LIN
2
;
Wanping CHEN
1
;
Kai ZHANG
1
;
Mengsha XIANG
1
Author Information
1. Taizhou Blood Center, Taizhou 318000, China
2. Taizhou Center for Disease Control, Taizhou 318000, China
- Publication Type:Journal Article
- Keywords:
low ferritin;
apheresis platelet;
blood donors;
interventions;
blood donation interval
- From:
Chinese Journal of Blood Transfusion
2025;38(11):1586-1591
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze characteristics of iron-deficient blood donors, implement targeted interventions, and evaluate their effectiveness, thereby providing a reference for formulating blood donor recruitment and care strategies. Methods: Based on serum ferritin (SF) test results, the apheresis platelet donors were divided into the low SF group (n=90; 45 males and 45 females) and the normal SF group (n=651; 510 males and 141 females). The results of related indicators of the two groups were compared and analyzed. Interventions for the low SF group included extending the blood donation interval to at least 45 days (group A) and oral iron supplementation combined with the extended donation interval implemented in group A (group B). Pre-intervention and post-intervention SF results were compared. Results: For both male and female donors, serum iron levels were significantly lower in the low SF group than those of the normal SF group, while the levels of transferrin, unsaturated iron binding capacity (UIBC) and total iron binding capacity (TIBC) were higher in the low SF group compared to the normal SF group. Some indicators related to red blood cells showed changes, with more evident alterations in females than in males. Twenty-eight donors in group A and 39 donors in group B completed the study after intervention. SF value in group A was (18.32±8.09) μg/L at baseline and (26.21±17.30) μg/L after intervention. Similarly, SF value in group B was (15.87±7.69) μg/L at baseline and (26.24±15.55) μg/L after intervention. In both groups, SF values after intervention were significantly higher than baseline values. However, the magnitude of change did not significantly differ between groups A and B. Conclusion: Other related indicators in blood donors with low ferritin have also experienced some changes, suggesting that some blood donors may have entered the stage of iron-deficient erythropoiesis. Extending blood donation interval facilitates the recovery of iron storage in low-ferritin apheresis platelet donors. Blood stations should develop care strategies for apheresis platelet donors, including, at a minimum, the prolonged blood donation interval for donors with low ferritin.
