A ten-year retrospective analysis of HCV infection among blood donors in Qinghai province
10.13303/j.cjbt.issn.1004-549x.2025.11.013
- VernacularTitle:青海省献血者人群HCV感染情况十年回顾分析
- Author:
Yingnan DANG
1
;
Shengju LI
1
;
Yanxia LI
1
;
Hailin WU
1
;
Shiyu WANG
2
;
Chenglin MA
3
;
Xianlin YE
4
Author Information
1. Qinghai Provincial Blood Center, Xining 810000, China
2. Qinghai Transportation Hospital, Xining 810000, China
3. Haidong Central Blood Station, Ping'an 810600, China
4. Shenzhen Blood Center, Shenzhen 518035, China
- Publication Type:Journal Article
- Keywords:
altitude;
ethnic groups;
hepatitis C virus (HCV);
enzyme-linked immunosorbent assay (ELISA);
nucleic acid testing (NAT)
- From:
Chinese Journal of Blood Transfusion
2025;38(11):1562-1566
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To retrospectively analyze the prevalence of hepatitis C virus (HCV) infection among voluntary blood donors in Qinghai Province over a ten-year period and to provide evidence for refining blood safety screening strategies. Methods: Blood samples from 362 066 blood donors in Qinghai collected between January 2015 and April 2024 were simultaneously screened using enzyme-linked immunosorbent assay (ELISA) and nucleic acid testing (NAT). Follow-up was conducted for donors with reactive HCV RNA screening results, and alanine transaminase (ALT) was detected by rate method. Results: The HCV positive rate among blood donors in Qinghai was 0.22%. Gender, marital status, number of blood donations, and educational level were associated with HCV infection. Significant differences in HCV positive rates were observed among donors across regions and ethnic groups. The HCV positive rate among donors in Golog Tibetan Autonomous Prefecture (with an average altitude of 4 330 m) was significantly higher than that in Xining (0.52% vs 0.21%, P<0.001). Positivity rates were also significantly higher in Salar (0.84%), Hui (0.81%), Zang (0.60%), and Tu (0.45%) ethnic groups compared to the Han ethnic group (0.17%) (P<0.001). The abnormal rate of ALT in HCV-positive donors was higher than in non-HCV donors (6.13% vs 1.55%) (P<0.001). Conclusion: The relatively high HCV positivity rate among blood donors in Qinghai highlights the need for further investigation into viral sources, risk factors, and transmission routes. Optimized screening strategies are essential to ensure blood safety.
