Improvement effect and mechanism of ghrelin on cognitive function in patients with depressive disorder
10.11886/scjsws20241106002
- VernacularTitle:胃饥饿素对抑郁症患者认知功能的改善作用及机制
- Author:
Aowen CHEN
1
;
Yongyi QIN
1
;
Juan DU
2
;
Jie FAN
3
;
Changquan HUANG
2
;
Yongsheng WANG
2
;
Rui HE
2
Author Information
1. North Sichuan Medical College， Nanchong 637000， China
2. Chengdu Second People's Hospital， Chengdu 610000， China
3. Chengdu University of Traditional Chinese Medicine， Chengdu 610000， China
- Publication Type:Journal Article
- Keywords:
Ghrelin;
Depressive disorder;
Cognitive function
- From:
Sichuan Mental Health
2025;38(5):476-480
- CountryChina
- Language:Chinese
-
Abstract:
Depressive disorder is a common psychiatric condition clinically characterized by impaired cognitive function， which profoundly affects patients' daily living and social functioning. Despite extensive research on the mechanism underlying the interaction between ghrelin and depressive disorder， comprehensive reviews， summary， and systematic organization of these findings remain lacking. To address this gap， this study aims to conduct a systematic evaluation of the effects and mechanisms of ghrelin on cognitive function in patients with depressive disorder， thereby providing references for targeted clinical interventions. On October 20， 2024， literature exploring the role and mechanisms of ghrelin in improving cognitive function in depressive disorder was sourced from the CNKI， PubMed and Web of Science databases， covering the period from the inception of the database till October 20， 2024. Two researchers independently conducted literature screening and data extraction. Ultimately， 9 articles were included in this review. The findings suggest that ghrelin improves cognitive function in patients with depressive disorder through multiple mechanisms， including mitigating inflammatory responses， modulating oxidative stress， and activating the cyclic adenosine monophosphate response element binding protein-brain-derived neurotrophic factor （CREB-BDNF） signaling pathway.
