Recent advances in pathophysiological mechanisms and treatment of post-stroke depression
10.11886/scjsws20241224001
- VernacularTitle:卒中后抑郁的病理生理机制与治疗策略研究进展
- Author:
Yu ZHU
1
;
Shifei ZHANG
2
;
Hong YE
3
;
Tianhao BAO
4
Author Information
1. The First Hospital of Kunming， Kunming 650000， China
2. The First Affiliated Hospital of Kunming Medical University， Kunming 650032， China
3. Kunming Medical University， Kunming 650500， China
4. Mental Hospital of Yunnan Province， Kunming 650224， China
- Publication Type:Review
- Keywords:
Post-stroke depression;
Pathophysiological mechanism;
Treatment
- From:
Sichuan Mental Health
2025;38(5):469-475
- CountryChina
- Language:Chinese
-
Abstract:
Post-stroke depression （PSD） represents a common and debilitating complication following stroke， substantially impeding neurorehabilitation outcomes and exerting a profound negative impact on patients' quality of life， while concurrently contributing to increased mortality rates. Despite a growing understanding of PSD， contemporary clinical management continues to encounter multifaceted challenges. This systematic review synthesizes extant literature to delineate pathophysiological mechanisms underlying PSD and to identify evidence-based interventions. By establishing a theoretical foundation， it aims to optimize early diagnostic protocols and personalized therapeutic regimens， thereby enhancing rehabilitation and therapeutic outcomes in stroke patients. Through rigorous evaluation of 14 original studies， this analysis comprehensively examines genetic factors， neurobiological aberrations， immunological factors， and psychosocial stressors contributing to PSD onset and progression， offering critical insights for developing comprehensive treatment strategies.［Funded by Science and Technology Plan Project of Yunnan Provincial Department of Science and Technology （number， 202101AY070001-048）］
