The incidence and influencing factors of postherpetic neuralgia in community-based populations aged 50 years and above in Shanghai
10.19428/j.cnki.sjpm.2025.24638
- VernacularTitle:上海市50岁及以上社区人群带状疱疹后神经痛发病及影响因素
- Author:
Miao JIANG
1
;
Qi ZHU
2
;
Yiling WU
2
;
Yonggen JIANG
2
;
Tao ZHANG
1
;
Genming ZHAO
1
Author Information
1. Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China
2. Songjiang District Center for Disease Control and Prevention, Shanghai 201600, China
- Publication Type:Journal Article
- Keywords:
herpes zoster;
postherpetic neuralgia;
cohort study;
influencing factor;
immune deficiency;
cumulative incidence rate
- From:
Shanghai Journal of Preventive Medicine
2025;37(9):725-730
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the incidence and influencing factors of postherpetic neuralgia (PHN) among herpes zoster (HZ) patients aged 50 years and above in the community-based population of Shanghai who had not received the recombinant zoster vaccine (RZV), so as to provide data support for formulating PHN prevention strategies. MethodsBased on baseline survey data, physical examinations, biochemical indicator tests, annual clinical diagnosis and treatment data from the Shanghai Suburban Adult Cohort, as well as the RZV vaccination data from the vaccination information platform of the Center for Disease Control and Prevention, the cumulative incidence rate of PHN was calculated. Logistic regression analyses were used to analyze the influencing factors of PHN. ResultsA total of 48 261 participants were included in this study, with 2 406 newly diagnosed HZ cases, among whom 11 had received at least one dose of RZV. Among 2 395 unvaccinated HZ patients, 262 new PHN cases were identified, with a cumulative incidence rate of 10.94% (95%CI: 9.72%‒12.26%). Factors influencing PHN incidence included age 70‒79 years (OR=2.069, 95%CI: 1.427‒3.028), history of immunosuppresant utilization (OR=1.592, 95%CI: 1.227‒2.072), and history of stroke (OR=1.657, 95%CI: 1.015‒2.605). For male patients, the influencing factors for PHN were age 70‒79 years (OR=2.319, 95%CI: 1.195‒4.802) and history of chronic bronchitis (OR=1.935, 95%CI: 1.010‒3.517), whereas, for female patients, age 70‒79 years (OR=1.767, 95%CI: 1.107‒2.831), history of immunosuppresant use (OR=1.603, 95%CI: 1.151‒2.245), history of stroke (OR=1.906, 95%CI: 1.059‒3.277), and alcohol consumption (OR=3.698, 95%CI: 1.093‒12.517) were influencing factors for PHN. ConclusionIndividuals with advanced age, history of immunosuppresant utilization, stroke, chronic bronchitis, and alcohol consumption are at high risk for PHN. These individuals should be prioritized for RZV vaccination to reduce the occurrence of PHN and improve their quality of life.
