Primary Cutaneous CD30+ Lymphoproliferative Disorders in South Korea: A Nationwide, Multi-Center, Retrospective, Clinical, and Prognostic Study
- Author:
Woo Jin LEE
1
;
Sook Jung YUN
;
Joon Min JUNG
;
Joo Yeon KO
;
Kwang Ho KIM
;
Dong Hyun KIM
;
Myung Hwa KIM
;
You Chan KIM
;
Jung Eun KIM
;
Chan-Ho NA
;
Je-Ho MUN
;
Jong Bin PARK
;
Ji-Hye PARK
;
Hai-Jin PARK
;
Dong Hoon SHIN
;
Jeonghyun SHIN
;
Sang Ho OH
;
Seok-Kweon YUN
;
Dongyoun LEE
;
Seok-Jong LEE
;
Seung Ho LEE
;
Young Bok LEE
;
Soyun CHO
;
Sooyeon CHOI
;
Jae Eun CHOI
;
Mi Woo LEE
;
On behalf of The Korean Society of Dermatopathology
Author Information
- Publication Type:Original Article
- From:Annals of Dermatology 2025;37(2):75-85
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Primary cutaneous CD30+ lymphoproliferative disorders (pcCD30-LPDs) are a diseases with various clinical and prognostic characteristics.
Objective:Increasing our knowledge of the clinical characteristics of pcCD30-LPDs and identifying potential prognostic variables in an Asian population.
Methods:Clinicopathological features and survival data of pcCD30-LPD cases obtained from 22 hospitals in South Korea were examined.
Results:A total of 413 cases of pcCD30-LPDs (lymphomatoid papulosis [LYP], n=237; primary cutaneous anaplastic large cell lymphoma [C-ALCL], n=176) were included. Ninety percent of LYP patients and roughly 50% of C-ALCL patients presented with multiple skin lesions. Both LYP and C-ALCL affected the lower limbs most frequently. Multiplicity and advanced T stage of LYP lesions were associated with a chronic course longer than 6 months. Clinical morphology with patch lesions and elevated serum lactate dehydrogenase were significantly associated with LPDs during follow-up in LYP patients. Extracutaneous involvement of C-ALCL occurred in 13.2% of patients. Lesions larger than 5 cm and increased serum lactate dehydrogenase were associated with a poor prognosis in C-ALCL. The survival of patients with C-ALCL was unaffected by the anatomical locations of skin lesions or other pathological factors.
Conclusion:The multiplicity or size of skin lesions was associated with a chronic course of LYP and survival among patients with C-ALCL.
