Pancreatic Dysfunction and Influencing Factors of Glucose Metabolism in children with β-thalassemia Major After Allogeneic Hematopoietic Stem Cell Transplantation
10.13471/j.cnki.j.sun.yat-sen.univ(med.sci).2025.0617
- VernacularTitle:重型β-地中海贫血儿童异基因造血干细胞移植后胰腺功能受损及影响因素
- Author:
Huilian DAI
1
;
Shaofen LIN
1
;
Lina ZHANG
1
;
Hui OU
1
;
Zulin LIU
1
;
Honggui XU
1
;
Ke HUANG
1
;
Liyang LIANG
1
Author Information
1. 中山大学孙逸仙纪念医院儿科,广东 广州 510000
- Publication Type:Journal Article
- Keywords:
allogeneic hematopoietic stem cell transplantation;
β-thalassemia major;
pedia;
age of HSCT;
abnormal glucose metabolism
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(6):1071-1078
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate and explore the characteristics and influencing factors of glucose metabolism in children with β-thalassemia major(β-TM)after allogeneic hematopoietic stem cell transplantation(allo-HSCT).[Methods]The follow-up data of 41 patients with β-TM who underwent HSCT at Hematopoietic Stem Cell Transplantation Department of Children's Medical Center of Sun Yat-sen Memorial Hospital,Sun Yat-sen University were retrospectively analyzed.Their glucose metabolism characteristics were evaluated through laboratory tests and the related influencing factors were analyzed.[Results]In the study,41.46％(17/41)of patients developed abnormal glucose homeostasis after HSCT.Among them,82.35％(14/17)characterized by insulin resistance,but no cases of diabetes mellitus were found.The results of insulin releasing test and oral glucose tolerance test(OGTT)showed that 45.00％(9/20)of patients had abnormal insulin releasing curve and 40.0％(8/20)had delayed serum glucose peak.The average age of HSCT in abnormal glucose homeostasis group was significantly older than that in the normal glucose homeostasis group[(8.8±3.9)years old vs(6.0±3.1)years old,P=0.015].[Conclusions]Patients with β-TM after HSCT may develop abnormal glucose homeostasis,consists largely of insulin resistance.The elder age of HSCT(≥7 years old)is a risk factor for abnormal glucose homeostasis in β-TM patients after HSCT.It is recommended to regularly monitor glucose metabolism indicators in β-TM children after HSCT,especially in elderly transplant recipients.
