Pancreatic Dysfunction and Influencing Factors of Glucose Metabolism in children with β-thalassemia Major After Allogeneic Hematopoietic Stem Cell Transplantation
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2025.0617
- VernacularTitle:重型β-地中海贫血儿童异基因造血干细胞移植后胰腺功能受损及影响因素
- Author:
Huilian DAI
1
;
Shaofen LIN
1
;
Lina ZHANG
1
;
Hui OU
1
;
Zulin LIU
1
;
Honggui XU
1
;
Ke HUANG
1
;
Liyang LIANG
1
Author Information
1. Department of Pediatrics，Sun Yat-sen Memorial Hospital，Sun Yat-sen University，Guangzhou 510000，China
- Publication Type:Journal Article
- Keywords:
allogeneic hematopoietic stem cell transplantation;
β- thalassemia major;
pedia;
age of HSCT;
abnormal glucose metabolism
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2025;46(6):1071-1078
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate and explore the characteristics and influencing factors of glucose metabolism in children with β-thalassemia major （β-TM） after allogeneic hematopoietic stem cell transplantation （allo-HSCT）. MethodsThe follow-up data of 41 patients with β-TM who underwent HSCT at Hematopoietic Stem Cell Transplantation Department of Children's Medical Center of Sun Yat-sen Memorial Hospital， Sun Yat-sen University were retrospectively analyzed. Their glucose metabolism characteristics were evaluated through laboratory tests and the related influencing factors were analyzed. ResultsIn the study， 41.46% （17/41） of patients developed abnormal glucose homeostasis after HSCT. Among them， 82.35% （14/17） characterized by insulin resistance， but no cases of diabetes mellitus were found. The results of insulin releasing test and oral glucose tolerance test（OGTT） showed that 45.00% （9/20） of patients had abnormal insulin releasing curve and 40.0% （8/20） had delayed serum glucose peak. The average age of HSCT in abnormal glucose homeostasis group was significantly older than that in the normal glucose homeostasis group ［（8.8±3.9） years old vs （6.0±3.1） years old， P=0.015］. ConclusionsPatients with β-TM after HSCT may develop abnormal glucose homeostasis， consists largely of insulin resistance. The elder age of HSCT （≥7 years old） is a risk factor for abnormal glucose homeostasis in β-TM patients after HSCT. It is recommended to regularly monitor glucose metabolism indicators in β-TM children after HSCT， especially in elderly transplant recipients.
